Evidence map›Paper›PMID 39338547›Full record

ArticleMicroorganisms2024

Update of the Genetic Variability of Monkeypox Virus Clade IIb Lineage B.1.

Fabio Scarpa, Ilenia Azzena, Alessandra Ciccozzi, Francesco Branda, Chiara Locci, Maria Perra, Noemi Pascale, Chiara Romano, Giancarlo Ceccarelli, Giuseppe Terrazzano and 4 more

Abstract read
In one paragraph

Article in Microorganisms, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Fabio ScarpaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3501-714X
Ilenia AzzenaDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.
Alessandra CiccozziDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Francesco BrandaUnit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Roma, Italy.ORCID 0000-0002-9485-3877
Chiara LocciDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Maria PerraDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Noemi PascaleDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.
Chiara RomanoUnit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Roma, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, University Hospital Policlinico Umberto I, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-5921-3180
Giuseppe TerrazzanoDepartment of Sciences, University of Basilicata,85100 Potenza, Italy.ORCID 0000-0003-3556-6891
Pier Luigi FioriDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6190-612X
Massimo CiccozziUnit of Medical Statistics and Molecular Epidemiology, Università Campus Bio-Medico di Roma, 00128 Roma, Italy.ORCID 0000-0003-3866-9239
Marco CasuDepartment of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-5042-4851
Daria SannaDepartment of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-3058-4663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From 1 January 2022 to 31 May 2024, the World Health Organization (WHO) reported 97,745 laboratory-confirmed Mpox cases, including 203 deaths, across 116 countries. Despite a 2.3% decrease in new cases in May 2024 compared to April 2024, significant regional variations persist. The African Region reported the highest proportion of new cases, while other regions experienced mixed trends. Phylogenomic analyses of the Mpox virus Clade IIb lineage B.1 reveal stable genetic variability with minimal diversification. The Bayesian Skyline Plot indicates a generally stable viral population size with a modest peak in late 2023, followed by a decline. In general, the data indicate that the MPXV outbreak is primarily localized within a few consistent geographic clusters. The virus's evolution is relatively slow, as indicated by its stable genetic variability, and Clade IIb lineage B.1 does not currently show signs of rapid genetic changes or population growth. The current low level of genetic diversity should not lead to complacency. Ongoing genomic surveillance is essential for effective outbreak management and understanding. This monitoring is crucial for identifying any shifts in the virus's behavior or transmission, allowing for prompt public health responses and adjustments. In addition, continued vigilance is necessary to detect any new variants that might influence the outbreak's trajectory.

Indexed as

clade IIbgeneticsgenome-based surveillancelineage B.1molecular epidemiologymonkeypoxphylodynamicphylogenyzoonotic disease

Identifiers

PMID39338547
PMCPMC11434445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.