Evidence map›Paper›PMID 39338372›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Plasminogen Activation Inhibitor-1 Promotes Resilience to Acute Oxidative Stress in Cerebral Arteries from Females.

Safa, Charles E Norton

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

SafaDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.
Charles E NortonDepartment of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA.ORCID 0000-0001-9442-4039

Funding

Female sex protects vascular smooth muscle cells from mitochondrial depolarization to oxidative stressR01NS134690 · NINDS · UNIVERSITY OF MISSOURI-COLUMBIA · PI Charles E Norton · 2024 to 2026
$1.1M
Alzheimer's Association AARG NTF-1148948NIH HHS R01 NS134690NINDS NIH HHS R01 NS134690
6 · The paper itself

Abstract

Plasminogen activation inhibitor-1 (PAI-1) plays a central role in thrombus formation leading to stroke; however, the contributions of PAI-1 to cellular damage in response to reactive oxygen species which are elevated during reperfusion are unknown. Given that PAI-1 can limit apoptosis, we hypothesized that PAI increases the resilience of cerebral arteries to H

Indexed as

calciumendothelial cellsmitochondrial depolarizationreactive oxygen speciessmooth muscle cells

Identifiers

PMID39338372
PMCPMC11434643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.