Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Cécile LetulleUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0009-0009-7367-3998
François-Xavier ToubletUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0000-0001-5630-6920
Aline PinonUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0000-0002-3123-7495
Soufyane HbaUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.
Aurélie LaurentUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.
Vincent SolUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0000-0003-0175-0156
Catherine FagnèreUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.
Benjamin RiouxUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0000-0002-4954-1380
Florent AllaisURD Agro-Biotechnologies Industrielles (ABI), CEBB (Centre Européen de Biotechnologie et de Bioéconomie), AgroParisTech, F-51110 Pomacle, France.ORCID 0000-0003-4132-6210
Sophie MichalletUniv. Grenoble Alpes, Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, F-38000 Grenoble, France.ORCID 0000-0001-9324-7958
Laurence LafanechèreUniv. Grenoble Alpes, Institute for Advanced Biosciences, Team Cytoskeletal Dynamics and Nuclear Functions, INSERM U1209, CNRS UMR5309, F-38000 Grenoble, France.ORCID 0000-0002-7902-7630
Youness LimamiLaboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco.ORCID 0000-0002-8816-3001
Mounia OudghiriLaboratory of Immunology and Biodiversity, Faculty of Sciences Ain Chock, Hassan II University, B.P. 2693, Maarif, Casablanca 20100, Morocco.
Mohamed OthmanUniversité Le Havre Normandie, Normandie Univ, URCOM UR 3221, INC3M, FR CNRS 3038, 25 Rue Philippe Lebon, BP 1123, F-76063 Le Havre Cedex, France.ORCID 0000-0002-8379-5704
Adam DaïchUniversité Le Havre Normandie, Normandie Univ, URCOM UR 3221, INC3M, FR CNRS 3038, 25 Rue Philippe Lebon, BP 1123, F-76063 Le Havre Cedex, France.ORCID 0000-0002-6942-0519
Bertrand LiagreUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.ORCID 0000-0003-4148-2598
Ata Martin LawsonUniversité Le Havre Normandie, Normandie Univ, URCOM UR 3221, INC3M, FR CNRS 3038, 25 Rue Philippe Lebon, BP 1123, F-76063 Le Havre Cedex, France.ORCID 0000-0002-1641-4190
Christelle PougetUniv. Limoges, LABCiS, UR 22722, Faculty of Pharmacy, F-87000 Limoges, France.
Funding
Normandie Université 000
6 · The paper itself
Abstract
In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this end, Claisen-Schmidt condensation was performed in basic or acidic conditions between the common starting material 3,4,5-trimethoxyacetophenone and appropriate aldehydes; this allowed the recovery of fifteen chalcones in moderate-good yields. The synthesized compounds were screened for their antiproliferative activity against colorectal and prostatic cancer cells, using a colorimetric MTT assay. Among the new chromonyl series, chalcone
Indexed as
3,4,5-trimethoxylated chalconesantiproliferative activityapoptosis inductioncolorectal and prostatic cancer cellsmicrotubule-depolymerizing agents
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Synthesis and Antiproliferative Effect of 3,4,5-Trimethoxylated Chalcones on Colorectal and Prostatic Cancer Cells. · full record | OpenQuestion