Evidence map›Paper›PMID 39338326›Full record

ReviewPharmaceuticals (Basel, Switzerland)2024

Drug Delivery Systems for Glaucoma: A Narrative Review.

Antonio M Fea, Veronica Vallino, Michela Cossu, Valentina Marica, Cristina Novarese, Michele Reibaldi, Francesco Petrillo

Registry-linked trialAbstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07690397 (GLAUCO-TECH Study), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07690397 phase4active not recruitingnot on this mapstarted 2026, after this paper: background citation

GLAUCO-TECH Study: Safety & Efficacy of Preservative-free vs. Preserved Dorzolamide-Timolol-Brimonidine. Impact on the Ocular Surface, Glaucoma Progression, Tear Proteomics, and AI/Chatbot-led Patient Follow-up.

TypeinterventionalSponsorTecnoquimicasRan2026 to 2027Enrolled140ConditionsPrimary Open-Angle Glaucoma (POAG), Ocular HypertensionArmsPreservative-free dorzolamide-timolol-brimonidine combination, Preservative dorzolamide-timolol-brimonidine combination
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Gasotransmitters in Glaucoma: A New Paradigm.Bulletin of pharmaceutical research · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antonio M FeaDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.
Veronica VallinoDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.
Michela CossuDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.
Valentina MaricaDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.
Cristina NovareseDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.
Michele ReibaldiDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.ORCID 0000-0003-1368-6729
Francesco PetrilloDepartment of Ophthalmology, "City of Health and Science" Hospital, 10126 Turin, Italy.ORCID 0000-0003-0446-2846

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glaucoma is one of the world's leading causes of blindness, and its management is challenging. The main objective is to lower intraocular pressure through medical, para-surgical, and surgical therapy. Medical therapy often represents the first line of treatment. Although effective in many cases, the eye drops are accompanied by significant problems. They require high patient compliance and can be associated with various side effects, limiting their efficacy. Consequently, the research for new drug delivery systems trying to overcome these limitations is ongoing: numerous devices are developing and gradually entering clinical practice. These new therapeutic options may offer better control of the intraocular pressure, with fewer side effects, and are less dependent on patients' compliance. Hence, the research in this field continues to flourish. This review summarizes the most recent findings in the scientific literature, underlines the role and possible limitations of the new glaucoma drug delivery systems in clinical practice, and recognizes their new horizons and perspectives.

Indexed as

conjunctival fornix delivery systemsdrug-laden contact lensesglaucomaintracameral delivery systemsperiocular drug delivery systemspunctal plug delivery systems

Identifiers

PMID39338326
PMCPMC11435076

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.