Rational Function-Based Approach for Integrating Tableting Reduced-Order Models with Upstream Unit Operations: Dry Granulation Case Study.

Sunidhi Bachawala, Rexonni B Lagare, Abigail B Delaney, Zoltan K Nagy, Gintaras V Reklaitis, Marcial Gonzalez

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Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

Rational Function-Based Approach for Integrating Tableting Reduced-Order Models with Upstream Unit Operations: Lubricants and Glidants Case Study.Pharmaceuticals (Basel, Switzerland) · 2025
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5 · Who and what money

Authors and funding

6 authors.

Sunidhi BachawalaSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0009-0003-9448-9758

Rexonni B LagareDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Abigail B DelaneyDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0009-0007-9649-4779

Zoltan K NagyDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Gintaras V ReklaitisDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Marcial GonzalezSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.

Funding

National Science Foundation 2140452

6 · The paper itself

Abstract

We present a systematic and automatic approach for integrating tableting reduced-order models with upstream unit operations. The approach not only identifies the upstream critical material attributes and process parameters that describe the coupling to the first order and, possibly, the second order, but it also selects the mathematical form of such coupling and estimates its parameters. Specifically, we propose that the coupling can be generally described by normalized bivariate rational functions. We demonstrate this approach for dry granulation, a unit operation commonly used to enhance the flowability of pharmaceutical powders by increasing granule size distribution, which, inevitably, negatively impacts tabletability by reducing the particle porosity and imparting plastic work. Granules of different densities and size distributions are made with a 10%

Indexed as

bivariate rational functionsdry granulationgranule size distributionreduced-order modelsribbon densitytableting

Identifiers

PMID39338321

DOI10.3390/ph17091158

PMCPMC11434797

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