Evidence map›Paper›PMID 39338302›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

The Properties of the Transient Outward, Inward Rectifier and Acetylcholine-Sensitive Potassium Currents in Atrial Myocytes from Dogs in Sinus Rhythm and Experimentally Induced Atrial Fibrillation Dog Models.

Zsófia Kohajda, Claudia Corici, Attila Kristóf, László Virág, Zoltán Husti, István Baczkó, László Sághy, András Varró, Norbert Jost

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In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zsófia KohajdaHUN-REN-SZTE Research Group of Cardiovascular Pharmacology, H-6701 Szeged, Hungary.
Claudia CoriciDepartment of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.
Attila KristófDepartment of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.
László VirágDepartment of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.
Zoltán HustiDepartment of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.
István BaczkóDepartment of Pharmacology & Pharmacotherapy, Albert Szent-Györgyi Medical School, University of Szeged, Dóm tér 12, P.O. Box 427, H-6701 Szeged, Hungary.ORCID 0000-0002-9588-0797
László SághyCardiac Electrophysiology Division, Department of Internal Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6701 Szeged, Hungary.
András VarróHUN-REN-SZTE Research Group of Cardiovascular Pharmacology, H-6701 Szeged, Hungary.
Norbert JostHUN-REN-SZTE Research Group of Cardiovascular Pharmacology, H-6701 Szeged, Hungary.ORCID 0000-0002-0838-2862

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAtrial fibrillation (AF) is the most common chronic/recurrent arrhythmia, which significantly impairs quality of life and increases cardiovascular morbidity and mortality. Therefore, the aim of the present study was to investigate the properties of three repolarizing potassium currents which were shown to contribute to AF-induced electrical remodeling, i.e., the transient outward (I

methodsAtrial remodeling and AF were induced by chronic (4-6 weeks of) right atrial tachypacing (400/min) in dogs. Transmembrane ionic currents were measured by applying the whole-cell patch-clamp technique at 37 °C.

resultsThe I

conclusionsIn our dog AF model, I

Indexed as

acetylcholine-sensitive potassium currentantiarrhythmic drugsatrial fibrillation-induced remodelingcardiac electrophysiologyproarrhythmia

Identifiers

PMID39338302
PMCPMC11434634

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.