Evidence map›Paper›PMID 39337959›Full record

ArticleLife (Basel, Switzerland)2024

In Vitro Evaluation of Anti-Hemolytic and Cytotoxic Effects of Traditional Mexican Medicinal Plant Extracts on Human Erythrocytes and Cell Cultures.

Joel H Elizondo-Luevano, Ramiro Quintanilla-Licea, Sandra L Castillo-Hernández, Eduardo Sánchez-García, Minerva Bautista-Villarreal, Georgia M González-Meza, Marcela A Gloria-Garza, Osvelia E Rodríguez-Luis, Maciej Ireneusz Kluz, Miroslava Kačániová

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Antitumor-Directed Fractionation ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Unlocking theMolecules (Basel, Switzerland) · 2025
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joel H Elizondo-LuevanoFaculty of Biological Sciences, Universidad Autónoma de Nuevo León, Cd., San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0003-2954-5939
Ramiro Quintanilla-LiceaFaculty of Biological Sciences, Universidad Autónoma de Nuevo León, Cd., San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0002-4379-6913
Sandra L Castillo-HernándezFaculty of Biological Sciences, Universidad Autónoma de Nuevo León, Cd., San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0001-8354-3200
Eduardo Sánchez-GarcíaFaculty of Biological Sciences, Universidad Autónoma de Nuevo León, Cd., San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0001-5751-9848
Minerva Bautista-VillarrealFaculty of Biological Sciences, Universidad Autónoma de Nuevo León, Cd., San Nicolás de los Garza 66455, Nuevo León, Mexico.ORCID 0000-0001-7975-1488
Georgia M González-MezaSchool of Engineering and Sciences, Tecnológico de Monterrey, Monterrey 64849, Nuevo León, Mexico.
Marcela A Gloria-GarzaFaculty of Odontology, Universidad Autónoma de Nuevo León, Dr. Eduardo Aguirre Pequeño, Monterrey 64460, Nuevo León, Mexico.
Osvelia E Rodríguez-LuisFaculty of Odontology, Universidad Autónoma de Nuevo León, Dr. Eduardo Aguirre Pequeño, Monterrey 64460, Nuevo León, Mexico.ORCID 0000-0002-5088-9851
Maciej Ireneusz KluzSchool of Medical & Health Sciences, University of Economics and Human Sciences in Warsaw, Okopowa 59, 01 043 Warszawa, Poland.
Miroslava KačániováSchool of Medical & Health Sciences, University of Economics and Human Sciences in Warsaw, Okopowa 59, 01 043 Warszawa, Poland.ORCID 0000-0002-4460-0222

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías Postdoctoral Scholarship I1200/331/2023Sistema Nacional de Investigadores CVU: 418935; CVU: 9867; CVU: 160538; CVU: 211323; CVU: 486943; CVU: 490688; CVU: 242099; CVU: 391708Slovak Research and Development Agency APVV-20-0058
6 · The paper itself

Abstract

Plant extracts of fifteen plants of ethnomedicinal use in Mexico were analyzed to provide scientific knowledge of their medicinal properties through the evaluation of different biological activities such as anti-hemolytic, antioxidant, and cytotoxic effects in normal cells. Therefore, methanolic extracts were obtained from each of the plants by the Soxhlet extraction. The hemolytic activity in human erythrocytes was evaluated, as was their potential to protect the erythrocyte membrane against the 2,2'-azobis (2-methylpropionamidine) dihydrochloride (AAPH) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) radicals. Finally, the toxicity of the extracts in normal cell cultures of African green monkey kidney cells (Vero) and peripheral blood mononuclear cells (PBMC) was determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction method. Most of the extracts showed low hemolytic activity and high anti-hemolytic activity as well as high selectivity indices (SI) and antioxidant effects. Extracts of

Indexed as

AAPHantioxidant activityDPPHerythrocytesethnopharmacologyhemolysisherbal medicinePBMCVero cells

Identifiers

PMID39337959
PMCPMC11433374

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.