Opportunities and Challenges in the Synthesis of Noble Metal Nanoparticles via the Chemical Route in Microreactor Systems.

The process of noble metal nanoparticle synthesis is complex and consists of at least two steps: slow nucleation and fast autocatalytic growth. The kinetics of these two processes depends on the reductant "power" and the addition of stabilizers, as well as other factors (e.g., temperature, pH, ionic strength). Knowing these parameters, it is possible to synthesize materials with appropriate physicochemical properties, which can be simply adjusted by the type of the used metal, particle morphology and surface property. This, in turn, affects the possibility of their applications in various areas of life, including medicine, catalysis, engineering, fuel cells, etc. However, in some cases, the standard route, i.e., the chemical reduction of a metal precursor carried out in the batch reactor, is not sufficient due to problems with temperature control, properties of reagents, unstable or dangerous intermediates and products, etc. Therefore, in this review, we focused on an alternative approach to their chemical synthesis provided by microreactor systems. The use of microreactors for the synthesis of noble metal nanomaterials (e.g., Ag, Au, Pt, Pd), obtained by chemical reduction, is analyzed, taking into account investigations carried out in recent years. A particular emphasis is placed on the processes in which the use of microreactors removed the limitations associated with synthesis in a batch reactor. Moreover, the opportunities and challenges related to the synthesis of noble nanomaterials in the microreactor system are underlined. This review discusses the advantages as well as the problems of nanoparticle synthesis in microreactors.