Evidence map›Paper›PMID 39337776›Full record

ArticleMicromachines2024

Investigating a Detection Method for Viruses and Pathogens Using a Dual-Microcantilever Sensor.

Luca Banchelli, Georgi Todorov, Vladimir Stavrov, Borislav Ganev, Todor Todorov

Abstract read
In one paragraph

Article in Micromachines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Luca BanchelliDepartment of Theory of Mechanisms and Machines, Faculty of Industrial Technology, Technical University of Sofia, 1797 Sofia, Bulgaria.
Georgi TodorovDepartment of Manufacturing Technology and Systems, Faculty of Industrial Technology, Technical University of Sofia, 1797 Sofia, Bulgaria.
Vladimir StavrovAMG Technology Ltd., Microelectronica Industrial Zone, 2140 Botevgrad, Bulgaria.
Borislav GanevDepartment of Electronics, Faculty of Electronic Engineering and Technologies, Technical University of Sofia, 1797 Sofia, Bulgaria.ORCID 0009-0001-3566-1197
Todor TodorovDepartment of Theory of Mechanisms and Machines, Faculty of Industrial Technology, Technical University of Sofia, 1797 Sofia, Bulgaria.ORCID 0000-0002-6275-476X

Funding

European Commission, Bulgaria's recovery and resilience plan BG-RRP-2.004-0005
6 · The paper itself

Abstract

Piezoresistive microcantilever sensors for the detection of viruses, pathogens, and trace chemical gasses, with appropriate measurement and signal processing methods, can be a powerful instrument with high speed and sensitivity, with in situ and real-time capabilities. This paper discusses a novel method for mass sensing on the order of a few femtograms, using a dual-microcantilever piezoresistive sensor with a vibrating common base. The two microcantilevers have controllably shifted natural frequencies with only one of them being active. Two active piezoresistors are located on the surfaces of each of the two flexures, which are specifically connected in a Wheatstone bridge with two more equivalent passive resistors located on the sensor base. A dedicated experimental system measures the voltages of the two half-bridges and, after determining their amplitude-frequency responses, finds the modulus of their differences. The modified amplitude-frequency response possesses a cusp point which is a function of the natural frequencies of the microcantilevers. The signal processing theory is derived, and experiments are carried out on the temperature variation in the natural frequency of the active microcantilever. Theoretical and experimental data of the temperature-frequency influence and equivalent mass with the same impact are obtained. The results confirm the sensor's applicability for the detection of ultra-small objects, including early diagnosis and prediction in microbiology, for example, for the presence of SARS-CoV-2 virus, other viruses, and pathogens. The versatile nature of the method makes it applicable to other fields such as medicine, chemistry, and ecology.

Indexed as

microcantileverpiezoresistorSARS-CoV-2vibrationvirus detection

Identifiers

PMID39337776
PMCPMC11434606

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.