Evidence map›Paper›PMID 39337715›Full record

ArticleInternational journal of molecular sciences2024

Synergistic Effect between the

Danira Toral-Rios, Pavel Pichardo-Rojas, Elizabeth Ruiz-Sánchez, Óscar Rosas-Carrasco, Rosa Carvajal-García, Dey Carol Gálvez-Coutiño, Nancy Lucero Martínez-Rodríguez, Ana Daniela Rubio-Chávez, Myr Alcántara-Flores, Arely López-Ramírez and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Danira Toral-RiosDepartment of Psychiatry, School of Medicine, Washington University, St. Louis, MO 63110, USA.ORCID 0000-0001-5156-6969
Pavel Pichardo-RojasThe Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.ORCID 0000-0002-0804-2825
Elizabeth Ruiz-SánchezNeurochemistry Laboratory, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Óscar Rosas-CarrascoGeriatric Assessment Center, Department of Health, Iberoamerican University, Mexico City 01219, Mexico.ORCID 0000-0002-0564-5882
Rosa Carvajal-GarcíaSINANK'AY Geriatric Center, Jurica, Santiago de Querétaro 76100, Mexico.
Dey Carol Gálvez-CoutiñoExperimental Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Nancy Lucero Martínez-RodríguezEpidemiological Research Unit in Endocrinology and Nutrition, Children's Hospital of Mexico Federico Gómez, Mexico City 06720, Mexico.ORCID 0000-0002-7840-983X
Ana Daniela Rubio-ChávezHigh Specialty Medical Unit (UMAE), Specialty Hospital, National Medical Center (CMN), XXI Century, Mexico City 06720, Mexico.
Myr Alcántara-FloresDepartment of Psychiatry, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Arely López-RamírezExperimental Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Alma Rosa Martínez-RosasCognition and Behavior Unit, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.
Ángel Alberto Ruiz-ChowDepartment of Psychiatry, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0002-6562-0935
Mario Alonso-VanegasDirector of the International Center for Epilepsy Surgery, HMG-Coyoacan Hospital, Mexico City 04380, Mexico.ORCID 0000-0002-7327-7014
Victoria Campos-PeñaExperimental Laboratory of Neurodegenerative Diseases, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez", Mexico City 14269, Mexico.ORCID 0000-0001-8282-7543

Funding

FONSEC SSA/IMSS/ISSSTE-CONACYT 069899 and 273182
6 · The paper itself

Abstract

Temporal Lobe Epilepsy (TLE) is a chronic neurological disorder characterized by recurrent focal seizures originating in the temporal lobe. Despite the variety of antiseizure drugs currently available to treat TLE, about 30% of cases continue to have seizures. The etiology of TLE is complex and multifactorial. Increasing evidence indicates that Alzheimer's disease (AD) and drug-resistant TLE present common pathological features that may induce hyperexcitability, especially aberrant hyperphosphorylation of tau protein. Genetic polymorphic variants located in genes of the microtubule-associated protein tau (

Indexed as

AllelesAlzheimer DiseaseApolipoprotein E4Glycogen Synthase Kinase 3 betatau ProteinsAdultAgedDrug Resistant EpilepsyEpilepsy, Temporal LobeFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedPolymorphism, Single NucleotideApolipoprotein E4Glycogen Synthase Kinase 3 betaGSK3B protein, humanMAPT protein, humantau ProteinsAlzheimer diseaseAPOE ε4 alleledrug-resistant Epilepsyepilepsyhippocampal sclerosisSNP

Identifiers

PMID39337715
PMCPMC11432663

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.