Evidence map›Paper›PMID 39337699›Full record

ArticleInternational journal of molecular sciences2024

Polymer Physics Models Reveal Structural Folding Features of Single-Molecule Gene Chromatin Conformations.

Mattia Conte, Alex Abraham, Andrea Esposito, Liyan Yang, Johan H Gibcus, Krishna M Parsi, Francesca Vercellone, Andrea Fontana, Florinda Di Pierno, Job Dekker and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Bridging spatial and temporal scales of developmental gene regulation.Current opinion in genetics & development · 2025
    Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mattia ConteDipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.ORCID 0000-0002-6670-9800
Alex AbrahamDipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.ORCID 0000-0003-3533-6543
Andrea EspositoDipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.ORCID 0000-0002-5903-8439
Liyan YangDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Johan H GibcusDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Krishna M ParsiDiabetes Center of Excellence and Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.ORCID 0000-0002-6002-3816
Francesca VercelloneDIETI, Università di Napoli Federico II, Via Claudio 21, 80125 Naples, Italy.
Andrea FontanaDipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.ORCID 0009-0004-1996-4800
Florinda Di PiernoDIETI, Università di Napoli Federico II, Via Claudio 21, 80125 Naples, Italy.
Job DekkerDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.
Mario NicodemiDipartimento di Fisica, Università di Napoli Federico II, and INFN Napoli, Complesso Universitario di Monte Sant'Angelo, 80126 Naples, Italy.ORCID 0000-0002-8416-6416

Funding

Center for 3D Structure and Physics of the GenomeU54DK107980 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB · 2015 to 2019
$14.9M
Center for 3D Structure and Physics of the GenomeUM1HG011536 · NHGRI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DEKKER, JOB, MIRNY, LEONID A · 2020 to 2024
$11.8M
Center for Integrated Multi-modal and Multi-scale Nucleome ResearchUM1HG011585 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DULAC, CATHERINE, LEIN, ED · 2020 to 2024
$6.7M
NHGRI NIH HHS UM1 HG011536NHGRI NIH HHS UM1 HG011585NIDDK NIH HHS U54 DK107980
6 · The paper itself

Abstract

Here, we employ polymer physics models of chromatin to investigate the 3D folding of a 2 Mb wide genomic region encompassing the human

Indexed as

ChromatinMolecular Dynamics SimulationNucleic Acid ConformationDNAHumansPolymersChromatinDNAPolymerschromatin foldingepigeneticsgene regulationphase separationpolymer physics

Identifiers

PMID39337699
PMCPMC11432541

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.