Evidence map›Paper›PMID 39337697›Full record

ArticleInternational journal of molecular sciences2024

Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells.

Guanyu Zhou, Tsutomu Shimura, Taiki Yoneima, Akiko Nagamachi, Akinori Kanai, Kazutaka Doi, Megumi Sasatani

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Guanyu ZhouDepartment of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 754-8553, Japan.
Tsutomu ShimuraDepartment of Environmental Health, National Institute of Public Health, Saitama 351-0197, Japan.ORCID 0000-0002-2418-2991
Taiki YoneimaSchool of Medicine, Hiroshima University, Hiroshima 754-8551, Japan.
Akiko NagamachiDepartment of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 754-8553, Japan.
Akinori KanaiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba 277-8561, Japan.
Kazutaka DoiDepartment of Radiation Regulatory Science Research, Institute for Radiological Sciences, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan.
Megumi SasataniDepartment of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 754-8553, Japan.ORCID 0000-0002-1219-1014

Funding

Initiative for Realizing Diversity in the Research Environment (Specific Correspondence Type), a support project for the Development of Human Resources in Science and Technology conducted by the Ministry of Education, Culture, Sports, Science and Technolo noneJapan Society for the Promotion of Science, JSPS KAKENHI 20K21846Japan Society for the Promotion of Science, JSPS KAKENHI 22H03754Japan Society for the Promotion of Science, JSPS KAKENHI 23H03542Japan Society for the Promotion of Science, JSPS KAKENHI 23K25008Japan Society for the Promotion of Science, JSPS KAKENHI 23K28232National Institute for Fusion Science Collaborative Research Program NIFS17KOCA002National Institute for Fusion Science Collaborative Research Program NIFS20KOCA004National Institute for Fusion Science Collaborative Research Program NIFS23HDCF005QST Research Collaboration noneResearch project on the Health Effects of Radiation organized by Ministry of the Environment, Japan. nonethe Program of the Network-Type Joint Usage/Research Center for Radiation Disaster Medical Science at Hiroshima University, Nagasaki University, and Fukushima Medical University. none
6 · The paper itself

Abstract

Age at exposure is a critical modifier of the risk of radiation-induced cancer. However, the effects of age on radiation-induced carcinogenesis remain poorly understood. In this study, we focused on tissue stem cells using

Indexed as

DNA DamageStem CellsAdult Stem CellsAge FactorsAnimalsApoptosisDNA RepairIntestinal MucosaIntestinesMiceMice, Inbred C57BLReceptors, G-Protein-CoupledTumor Suppressor Protein p53Lgr5 protein, mouseReceptors, G-Protein-CoupledTumor Suppressor Protein p53age at exposureapoptosiscell cycleDNA damage responseDNA repairgene expression variabilityintestinal cryptsLgr5+ intestinal stem cellsp53 activationradiationstem cell

Identifiers

PMID39337697
PMCPMC11431935

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.