Evidence map›Paper›PMID 39337667›Full record

ArticleInternational journal of molecular sciences2024

Histologic Evaluation of Thyroid Nodules Treated with Thermal Ablation: An Institutional Experience.

Fernanda Russotto, Vincenzo Fiorentino, Cristina Pizzimenti, Marina Gloria Micali, Mariausilia Franchina, Ludovica Pepe, Giuseppe Riganati, Walter Giordano, Emilia Magliolo, Serenella Ristagno and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
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  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fernanda RussottoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Vincenzo FiorentinoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-1132-1761
Cristina PizzimentiPathology Unit, Papardo Hospital, 98158 Messina, Italy.ORCID 0000-0002-4387-7174
Marina Gloria MicaliDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Mariausilia FranchinaDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0009-0008-5806-2307
Ludovica PepeDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Giuseppe RiganatiDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Walter GiordanoDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0009-0005-8530-2474
Emilia MaglioloDepartment of Pathology, "San Vincenzo" Hospital, 98039 Taormina, Italy.
Serenella RistagnoDepartment of Oncology, Section of Endocrine Surgery, "San Vincenzo" Hospital, 98039 Taormina, Italy.
Esther Diana RossiDivision of Anatomic Pathology and Histology, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A.Gemelli IRCCS, 00168 Rome, Italy.ORCID 0000-0003-3819-4229
Giovanni TuccariDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-1561-4246
Maurizio MartiniDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-6260-6310
Antonio IeniDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Guido FaddaDepartment of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thyroid nodules are a common, benign condition with a higher prevalence in women, individuals with iodine deficiency, and radiation exposure. Treatment options for benign thyroid nodules include pharmaceutical therapy, thyroidectomy, and thermal ablation (TA). TA, including laser ablation (LA), radiofrequency ablation (RFA), and microwave ablation (MWA), is a procedure that uses heat to cause tissue necrosis. It is commonly used for large, firm, benign, non-functioning thyroid nodules that cause severe symptoms or pain when surgery is not recommended or desired. When thyroid nodules do not respond to TA, they undergo surgery to resolve the symptoms and clarify the diagnosis. This study aims to analyze the histological alterations found in surgically excised TA-treated thyroid nodules and to evaluate the morphological criteria of differential diagnosis between benign and malignant nodules, establishing whether the alterations observed on the histological sample are a consequence of TA or indicative of neoplastic disease. For this purpose, the adoption of ancillary methods, such as immunohistochemistry, is fundamental to distinguish the artifacts induced by TA from the typical morphological characteristics of malignant neoplasms.

Indexed as

Thyroid NoduleAblation TechniquesAdultAgedDiagnosis, DifferentialFemaleHumansMaleMicrowavesMiddle AgedRadiofrequency AblationThyroid Neoplasmsdifferential diagnosishistological examinationthermal ablationthyroid nodules

Identifiers

PMID39337667
PMCPMC11432105

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.