Evidence map›Paper›PMID 39337636›Full record

ArticleInternational journal of molecular sciences2024

Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation.

Erika L Garcia-Villatoro, Zachary S Bomstein, Kimberly F Allred, Evelyn S Callaway, Stephen Safe, Robert S Chapkin, Arul Jayaraman, Clinton D Allred

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Association of CCL21Cancer immunology, immunotherapy : CII · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erika L Garcia-VillatoroDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Zachary S BomsteinDepartment of Nutrition, University of North Carolina Greensboro, Greensboro, NC 27412, USA.
Kimberly F AllredDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Evelyn S CallawayDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Stephen SafeDepartment of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77840, USA.ORCID 0000-0002-2115-3060
Robert S ChapkinDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.ORCID 0000-0002-6515-3898
Arul JayaramanDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.
Clinton D AllredDepartment of Nutrition, Texas A&M University, College Station, TX 77843, USA.

Funding

Texas A&M Center for Environmental Health Research (TiCER)P30ES029067 · NIEHS · TEXAS A&M UNIVERSITY · PI Weston W Porter · 2019 to 2026
$13.0M
Plasma membrane therapy: Disruption of Wnt associated receptor spatiotemporal organization by membrane targeted dietary bioactives (MTDB)R35CA197707 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN · 2016 to 2022
$6.3M
Diet induced modifications of microbiota metabolites in colon tumorigenesisR01CA202697 · NCI · TEXAS A&M AGRILIFE RESEARCH · PI ALLRED, CLINTON D, CHAPKIN, ROBERT STEPHEN · 2016 to 2020
$2.0M
Role of Aryl Hydrocarbon Receptor in Microbiota-Colon Stem Cell InteractionsR01ES025713 · NIEHS · TEXAS A&M AGRILIFE RESEARCH · PI CHAPKIN, ROBERT STEPHEN, JAYARAMAN, ARUL · 2016 to 2020
$2.0M
Novel effects of xenoestrogens and gut microbiota derived estrogenic compounds in colonic inflammationR56ES033052 · NIEHS · TEXAS ENGINEERING EXPERIMENT STATION · PI ALLRED, CLINTON D, JAYARAMAN, ARUL · 2022 to 2022
$375k
Cancer Prevention and Research Institute of Texas RP160589NCI NIH HHS R01 CA202697NCI NIH HHS R01-CA202697, R35-CA197707NCI NIH HHS R35 CA197707NIEHS NIH HHS P30 ES029067NIEHS NIH HHS R01 ES025713NIEHS NIH HHS R56 ES033052NIEHS NIH HHS R56-ES033052, R01-ES025713
6 · The paper itself

Abstract

Tertiary lymphoid tissues (TLTs) are adaptive immune structures that develop during chronic inflammation and may worsen or lessen disease outcomes in a context-specific manner. Immune cell activity governing TLT formation in the intestines is dependent on immune cell aryl hydrocarbon receptor (AhR) activation. Homeostatic immune cell activity in the intestines is further dependent on ligand activation of AhR in intestinal epithelial cells (IECs), yet whether AhR activation and signaling in IECs influences the formation of TLTs in the presence of dietary AhR ligands is not known. To this end, we used IEC-specific AhR deletion coupled with a mouse model of dextran sodium sulfate (DSS)-induced colitis to understand how dietary AhR ligand 3, 3'-diindolylmethane (DIM) influenced TLT formation. DIM consumption increased the size of TLTs and decreased T-cell aggregation to TLT sites in an IEC-specific manner. In DSS-exposed female mice, DIM consumption increased the expression of genes implicated in TLT formation (Interleukin-22,

Indexed as

ColitisDextran SulfateIndolesInterleukin-22Intestinal MucosaReceptors, Aryl HydrocarbonTertiary Lymphoid StructuresAnimalsBasic Helix-Loop-Helix ProteinsChemokine CXCL13ColonDisease Models, AnimalFemaleInterleukinsMaleMice3,3'-diindolylmethaneAhr protein, mouseBasic Helix-Loop-Helix ProteinsChemokine CXCL13Cxcl13 protein, mouseDextran SulfateIndolesInterleukin-22InterleukinsReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorcolonDIMintestinal epitheliumtertiary lymphoid tissues

Identifiers

PMID39337636
PMCPMC11432480

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.