Evidence map›Paper›PMID 39337619›Full record

ArticleInternational journal of molecular sciences2024

Interferon-Gamma-Inducible Protein-10 (IP-10) and Tumor Necrosis Factor-α (TNF-α) as Serological Predictors of Active Disease Status in Localized Scleroderma.

Brittany Ashe, Christina Kelsey Zigler, Jonathan Yabes, Kelsey Magee, Katherine Kurzinski, Kathryn S Torok

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brittany AsheDepartment of Pediatrics (Rheumatology), University of Pittsburgh, Pittsburgh, PA 15224, USA.
Christina Kelsey ZiglerDepartment of Physical Medicine & Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
Jonathan YabesDepartment of Medicine (Biostatistics), University of Pittsburgh, Pittsburgh, PA 15261, USA.
Kelsey MageeDepartment of Medicine (Psychiatry), University of Pittsburgh, Pittsburgh, PA 15261, USA.ORCID 0000-0003-4220-3984
Katherine KurzinskiDepartment of Pediatrics (Nephrology), University of Pittsburgh, Pittsburgh, PA 15224, USA.
Kathryn S TorokDepartment of Pediatrics (Rheumatology), University of Pittsburgh, Pittsburgh, PA 15224, USA.

Funding

Ancillary studies to define dysregulated immune and fibrotic pathways in a well-characterized morphea cohortR01AR078560 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACOBE, HEIDI T, TOROK, KATHRYN S. · 2021 to 2024
$1.4M
Refining outcome measures through observational cohorts to advance trials in morpheaR01AR073516 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JACOBE, HEIDI T, TOROK, KATHRYN S. · 2019 to 2021
$641k
T-helper cell cytokine profile in localized sclerodermaK23AR059722 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TOROK, KATHRYN S. · 2010 to 2014
$629k
NIAMS NIH HHS K23 AR059722NIAMS NIH HHS R01 AR073516NIH HHS 1R01AR073516-20A1NIH HHS 1R01AR078560-21A1The Nancy Taylor Foundation for Chronic Diseases Inc 01
6 · The paper itself

Abstract

We investigated the ability of a panel of immune-related cytokines and chemokines to predict the disease activity state in localized scleroderma (LS) subjects followed longitudinally. A total of 194 sera samples were obtained from 45 LS subjects with diverse types of LS (40% linear, 20% mixed, 16% craniofacial, 13% generalized, and 11% circumscribed) in our cohort. Cytokines/chemokines that were significantly elevated at the baseline active disease visit compared to the inactive disease state at follow-up were Interferon-Gamma-Inducible Protein (IP)-10 (

Indexed as

BiomarkersChemokine CXCL10Scleroderma, LocalizedTumor Necrosis Factor-alphaAdultAgedFemaleHumansMaleMiddle AgedBiomarkersChemokine CXCL10CXCL10 protein, humanTumor Necrosis Factor-alphabiomarkercytokinedisease activityinterferon-gamma-inducible protein-10localized sclerodermamorpheatumor necrosis factor-α

Identifiers

PMID39337619
PMCPMC11432045

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.