Evidence map›Paper›PMID 39337615›Full record

ArticleInternational journal of molecular sciences2024

Enhancing Lung Recellularization with Mesenchymal Stem Cells via Photobiomodulation Therapy: Insights into Cytokine Modulation and Sterilization.

Leticia L Guimarães, Auriléia A Brito, Andressa D Cereta, Ana Paula L Oliveira, João Pedro R Afonso, Diego A C P G Mello, Iransé Oliveira-Silva, Carlos H M Silva, Rodrigo F Oliveira, Deise A A P Oliveira and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. The roles of glycerophospholipids in the aging retina and age-related macular degeneration.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Leticia L GuimarãesSchool of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-220, SP, Brazil.
Auriléia A BritoPost-Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University (UNINOVE), São Paulo 17011-102, SP, Brazil.
Andressa D CeretaSchool of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-220, SP, Brazil.
Ana Paula L OliveiraPost-Graduate Program in Biophotonics Applied to Health Sciences, Nove de Julho University (UNINOVE), São Paulo 17011-102, SP, Brazil.
João Pedro R AfonsoHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.
Diego A C P G MelloHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.
Iransé Oliveira-SilvaHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.ORCID 0000-0003-2692-1548
Carlos H M SilvaHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.
Rodrigo F OliveiraHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.
Deise A A P OliveiraHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.
Rodolfo de Paula VieiraHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-6379-1143
Dante Brasil SantosHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.ORCID 0000-0001-9909-4403
Giuseppe InsalacoInstitute of Translational Pharmacology, National Research Council of Italy (CNR), 90146 Palermo, Italy.ORCID 0000-0002-9506-2233
Luís V F OliveiraHuman Movement and Rehabilitation, Post-Graduate Program, Evangelic University of Goiás, UniEVANGELICA, Anápolis 75083-515, GO, Brazil.ORCID 0000-0002-3852-9415
Renata Kelly da PalmaSchool of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo 05508-220, SP, Brazil.ORCID 0000-0002-4799-0385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several lung diseases can cause structural damage, making lung transplantation the only therapeutic option for advanced disease stages. However, the transplantation success rate remains limited. Lung bioengineering using the natural extracellular matrix (ECM) of decellularized lungs is a potential alternative. The use of undifferentiated cells to seed the ECM is practical; however, sterilizing the organ for recellularization is challenging. Photobiomodulation therapy (PBMT) may offer a solution, in which the wavelength is crucial for tissue penetration. This study aimed to explore the potential of optimizing lung recellularization with mesenchymal stem cells using PBMT (660 nm) after sterilization with PBMT (880 nm). The lungs from C57BL/6 mice were decellularized using 1% SDS and sterilized using PBMT (880 nm, 100 mW, 30 s). Recellularization was performed in two groups: (1) recellularized lung and (2) recellularized lung + 660 nm PBMT (660 nm, 100 mW, 30 s). Both were seeded with mesenchymal stem cells from human tooth pulp (DPSc) and incubated for 24 h at 37 °C and 5% CO

Indexed as

CytokinesLow-Level Light TherapyLungMesenchymal Stem CellsMice, Inbred C57BLAnimalsExtracellular MatrixHumansMesenchymal Stem Cell TransplantationMiceSterilizationTissue EngineeringCytokinesdecellularizationextracellular matrixlungphotobiomodulation therapy

Identifiers

PMID39337615
PMCPMC11432310

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.