Nebulized Lipopolysaccharide Causes Delayed Cortical Neuroinflammation in a Murine Model of Acute Lung Injury.

Katharina Ritter, René Rissel, Miriam Renz, Alexander Ziebart, Michael K E Schäfer, Jens Kamuf

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Exploiting the Zebrafish Model for Sepsis Research: Insights into Pathophysiology and Therapeutic Potentials.Drug design, development and therapy · 2024
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5 · Who and what money

Authors and funding

6 authors.

Katharina RitterDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.

René RisselDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.

Miriam RenzDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.

Alexander ZiebartDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.

Michael K E SchäferDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.ORCID 0000-0001-6055-6244

Jens KamufDepartment of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University, Langenbeckstrasse 1, 55131 Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lung injury caused by respiratory infection is a major cause of hospitalization and mortality and a leading origin of sepsis. Sepsis-associated encephalopathy and delirium are frequent complications in patients with severe lung injury, yet the pathogenetic mechanisms remain unclear. Here, 70 female C57BL/6 mice were subjected to a single full-body-exposure with nebulized lipopolysaccharide (LPS). Neuromotor impairment was assessed repeatedly and brain, blood, and lung samples were analyzed at survival points of 24 h, 48 h, 72 h, and 96 h after exposure. qRT-PCR revealed increased mRNA-expression of

Indexed as

Acute Lung InjuryDisease Models, AnimalLipopolysaccharidesMice, Inbred C57BLAnimalsCerebral CortexFemaleInterleukin-1betaLungMiceNebulizers and VaporizersNeuroinflammatory DiseasesToll-Like Receptor 4Tumor Necrosis Factor-alphaInterleukin-1betaLipopolysaccharidesToll-Like Receptor 4Tumor Necrosis Factor-alphalipopolysaccharidelung injurymiceneuroinflammation

Identifiers

PMID39337602

DOI10.3390/ijms251810117

PMCPMC11432715

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