Evidence map›Paper›PMID 39337517›Full record

ArticleInternational journal of molecular sciences2024

Systematic Evaluation of Regiochemistry and Lipidation of Aryl Trehalose Mincle Agonists.

Asia Marie S Riel, Viktoria Rungelrath, Tamer A Elwaie, Omer K Rasheed, Linda Hicks, George Ettenger, Dai-Chi You, Mira Smith, Cassandra Buhl, Walid Abdelwahab and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Synthetic Ligands of Myeloid C-Type Lectin Receptors.Chembiochem : a European journal of chemical biology · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Asia Marie S RielDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Viktoria RungelrathDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Tamer A ElwaieDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Omer K RasheedDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0003-4928-5580
Linda HicksDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0002-0822-491X
George EttengerDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0002-0517-2843
Dai-Chi YouDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0003-4633-3559
Mira SmithDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Cassandra BuhlDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Walid AbdelwahabDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Shannon M MillerDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Alyson J SmithDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
David BurkhartDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.
Jay T EvansDepartment of Biomedical and Pharmaceutical Sciences, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0001-6602-0272
Kendal T RyterDepartment of Chemistry and Biochemistry, Center for Translational Medicine, University of Montana, Missoula, MT 59812, USA.ORCID 0000-0003-2718-2759

Funding

Surveillance genome sequencing to detect SARS-CoV-2 virus variants in MontanaP30GM140963 · NIGMS · UNIVERSITY OF MONTANA · PI BOWLER, BRUCE E · 2021 to 2025
$6.9M
NIAID NIH HHS HHSN272201400050CNIGMS NIH HHS P30 GM140963NIH HHS HHSN272201400050C
6 · The paper itself

Abstract

The Macrophage-Inducible C-type Lectin receptor (Mincle) plays a critical role in innate immune recognition and pathology, and therefore represents a promising target for vaccine adjuvants. Innovative trehalose-based Mincle agonists with improved pharmacology and potency may prove useful in the development of Th17-mediated adaptive immune responses. Herein, we report on in vitro and in silico investigations of specific Mincle ligand-receptor interactions required for the effective receptor engagement and activation of Th17-polarizing cytokines. Specifically, we employed a library of trehalose benzoate scaffolds, varying the degree of aryl lipidation and regiochemistry that produce inflammatory cytokines in a Mincle-dependent fashion. In vitro interleukin-6 (IL-6) cytokine production by human peripheral blood mononuclear cells (hPBMCs) indicated that the lipid regiochemistry is key to potency and maximum cytokine output, with the tri-substituted compounds inducing higher levels of IL-6 in hPBMCs than the di-substituted derivatives. Additionally, IL-6 production trended higher after stimulation with compounds that contained lipids ranging from five to eight carbons long, compared to shorter (below five) or longer (above eight) carbon chains, across all the substitution patterns. An analysis of the additional cytokines produced by hPBMCs revealed that compound

Indexed as

Lectins, C-TypeLeukocytes, MononuclearTrehaloseCytokinesHumansInterleukin-6Membrane ProteinsMolecular Docking SimulationReceptors, ImmunologicCLEC4D protein, humanCytokinesInterleukin-6Lectins, C-TypeMembrane ProteinsReceptors, ImmunologicTrehaloseadjuvantagonistMincletrehalose

Identifiers

PMID39337517
PMCPMC11432005

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.