Evidence map›Paper›PMID 39337515›Full record

ArticleInternational journal of molecular sciences2024

Modulation of the Cardiovascular Risk in Type 1 Diabetic Rats by Endurance Training in Combination with the Prebiotic Xylooligosaccharide.

Mariya Choneva, Slavi Delchev, Petar Hrischev, Ivica Dimov, Krasimir Boyanov, Iliyan Dimitrov, Fanka Gerginska, Katerina Georgieva, Mariana Bacelova, Anelia Bivolarska

Abstract read
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Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mariya ChonevaDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-5489-8106
Slavi DelchevDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0001-8607-6986
Petar HrischevDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Ivica DimovDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Krasimir BoyanovDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Iliyan DimitrovDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0001-8988-0072
Fanka GerginskaDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Katerina GeorgievaDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.
Mariana BacelovaDepartment of Physiology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0003-4461-2343
Anelia BivolarskaDepartment of Medical Biochemistry, Faculty of Pharmacy, Medical University of Plovdiv, 4000 Plovdiv, Bulgaria.ORCID 0000-0002-2157-3858

Funding

Medical University of Plovdiv HO-07/2019
6 · The paper itself

Abstract

Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study is to evaluate the effect of endurance training and prebiotic xylooligosaccharide (XOS) on the activity of key oxidative enzymes, myocardial collagen, and glycogen distribution as well as some serum biochemical risk markers in streptozotocin-induced type 1 diabetic rats. Male Wistar rats (n = 36) were divided into four diabetic groups (n = 9): sedentary diabetic rats on a normal diet (SDN), trained diabetic rats on a normal diet (TDN), trained diabetic rats on a normal diet with an XOS supplement (TD-XOS), and sedentary diabetic rats with an XOS supplement (SD-XOS). The results show that aerobic training managed to increase the enzyme activity of respiratory Complex I and II and the lactate dehydrogenase in the cardiomyocytes of the diabetic rats. Furthermore, the combination of exercise and XOS significantly decreased the collagen and glycogen content. No significant effects on blood pressure, heart rate or markers of inflammation were detected. These results demonstrate the beneficial effects of exercise, alone or in combination with XOS, on the cardiac mitochondrial enzymology and histopathology of diabetic rats.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Endurance TrainingGlucuronatesOligosaccharidesPhysical Conditioning, AnimalPrebioticsRats, WistarAnimalsCardiovascular DiseasesDiabetic CardiomyopathiesGlycogenMaleRatsGlucuronatesGlycogenOligosaccharidesPrebioticsxylooligosaccharidediabetic cardiomyopathyendurance trainingglycogen contentmitochondrial functionmyocardial fibrosistype 1 diabetesxylooligosaccharides

Identifiers

PMID39337515
PMCPMC11432573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.