Evidence map›Paper›PMID 39337512›Full record

ArticleInternational journal of molecular sciences2024

Circulating microRNAs in Carotid Atherosclerosis: Complex Interplay and Possible Associations with Atherothrombotic Stroke.

Marine M Tanashyan, Alla A Shabalina, Vladislav A Annushkin, Andrey S Mazur, Polina I Kuznetsova, Anton A Raskurazhev

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marine M TanashyanResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.ORCID 0000-0002-5883-8119
Alla A ShabalinaLaboratory of Hemorheology, Hemostasis and Pharmacokinetics with Clinical Laboratory Diagnostics, Research Center of Neurology, 80 Volokolamskoye Shosse, 125367 Moscow, Russia.
Vladislav A AnnushkinResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.
Andrey S MazurResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.ORCID 0000-0001-8960-721X
Polina I KuznetsovaResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.
Anton A RaskurazhevResearch Center of Neurology, 80, Volokolamskoe Shosse, 125367 Moscow, Russia.ORCID 0000-0003-0522-767X

Funding

Russian Science Foundation grant No. 23-25-00477, https://rscf.ru/en/project/23-25-00477/
6 · The paper itself

Abstract

Atherosclerosis is a chronic inflammatory disorder which remains the main cause of cardiovascular morbidity and mortality, with carotid atherosclerosis (CA) being a major cause of ischemic stroke. Epigenetic regulation plays a significant role in CA progression and stroke, yet the impact of circulating microRNA expression, associated with atherogenesis, has not been clearly defined. We included 81 patients with moderate-severe CA (mean age 67 ± 7 years, 53% male), 42% of whom had prior ipsilateral ischemic stroke (i.e., were symptomatic). A total of 24 miRs were identified and their plasma expression levels were measured. We observed that several microRNAs were up-regulated in stroke survivors, namely miR-200c-3p (30.6 vs. 29.7,

Indexed as

Carotid Artery DiseasesCirculating MicroRNAAgedBiomarkersFemaleHumansMaleMicroRNAsMiddle AgedStrokeBiomarkersCirculating MicroRNAMicroRNAsbiomarkerscarotid atherosclerosiscerebrovascular diseasemicroRNAstroke

Identifiers

PMID39337512
PMCPMC11432131

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.