Evidence map›Paper›PMID 39337490›Full record

ArticleInternational journal of molecular sciences2024

Tracking Response and Resistance in Acute Myeloid Leukemia through Single-Cell DNA Sequencing Helps Uncover New Therapeutic Targets.

Samantha Bruno, Enrica Borsi, Agnese Patuelli, Lorenza Bandini, Manuela Mancini, Dorian Forte, Jacopo Nanni, Martina Barone, Alessandra Grassi, Gianluca Cristiano and 12 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Samantha BrunoDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0001-6375-0595
Enrica BorsiIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.ORCID 0000-0003-3314-0037
Agnese PatuelliDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Lorenza BandiniDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Manuela ManciniIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.
Dorian ForteDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-8443-605X
Jacopo NanniDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Martina BaroneIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.
Alessandra GrassiDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Gianluca CristianoDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Claudia VenturiDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Valentina RobustelliIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.ORCID 0000-0001-6406-4888
Giulia AtzeniDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Cristina MoscaDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Sara De SantisDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Cecilia MonaldiDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Andrea PolettiDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0002-0753-1248
Carolina TerragnaIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.
Antonio CurtiIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.
Michele CavoDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.ORCID 0000-0003-4514-3227
Simona SoveriniDepartment of Medical and Surgical Science (DIMEC), University of Bologna, 40138 Bologna, Italy.
Emanuela OttavianiIstituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Azienda Ospedaliero, Universitaria di Bologna, Istituto di Ematologia "Seràgnoli", 940138 Bologna, Italy.ORCID 0000-0002-1879-5417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute myeloid leukemia (AML) is an aggressive hematologic neoplasia with a complex polyclonal architecture. Among driver lesions, those involving the

Indexed as

Aniline CompoundsDrug Resistance, Neoplasmfms-Like Tyrosine Kinase 3Leukemia, Myeloid, AcuteMutationProtein Kinase InhibitorsStaurosporineGTP PhosphohydrolasesHumansMembrane ProteinsProto-Oncogene Proteins c-kitPyrazinesSequence Analysis, DNASingle-Cell AnalysisAniline CompoundsFLT3 protein, humanfms-Like Tyrosine Kinase 3gilteritinibGTP PhosphohydrolasesKIT protein, humanMembrane ProteinsmidostaurinNRAS protein, humanProtein Kinase InhibitorsProto-Oncogene Proteins c-kitPyrazinesStaurosporineacute myeloid leukemiaclonal architectureclonal evolutionFLT3 mutationstyrosine kinase inhibitors

Identifiers

PMID39337490
PMCPMC11432296

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.