Evidence map›Paper›PMID 39337466›Full record

ArticleInternational journal of molecular sciences2024

Dysregulated S100A9 Expression Impairs Matrix Deposition in Chronic Wounds.

Sandra Franz, Marta Torregrossa, Ulf Anderegg, Anastasia Ertel, Anja Saalbach

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sandra FranzDepartment of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.ORCID 0000-0002-3449-2723
Marta TorregrossaDepartment of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.ORCID 0000-0001-8412-3646
Ulf AndereggDepartment of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.ORCID 0000-0002-3993-9192
Anastasia ErtelDepartment of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.
Anja SaalbachDepartment of Dermatology, Venereology and Allergology, Max Bürger Research Centre, Medical Faculty, University Leipzig, Johannisallee 30, 04103 Leipzig, Germany.ORCID 0000-0002-1084-3875

Funding

Deutsche Forschungsgemeinschaft FR2671/5-1Deutsche Forschungsgemeinschaft SA863/7-1Hautnetz 2023
6 · The paper itself

Abstract

Chronic non-healing wounds are characterized by persistent inflammation, excessive matrix-degrading proteolytic activity and compromised extracellular matrix (ECM) synthesis. Previous studies showed that S100A8/A9 are strongly dysregulated in delayed wound healing and impair the proper function of immune cells. Here, we demonstrate an unrecognized pathological function of

Indexed as

Calgranulin BExtracellular MatrixFibroblastsWound HealingAnimalsCalgranulin AChronic DiseaseDisease Models, AnimalHumansMiceMice, Inbred C57BLSkinToll-Like Receptor 4Calgranulin ACalgranulin BS100A9 protein, humanS100A9 protein, mouseToll-Like Receptor 4chronic woundsdiabetesextracellular matrixfibroblastsiron overloadS100A8S100A9

Identifiers

PMID39337466
PMCPMC11432490

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.