Evidence map›Paper›PMID 39337452›Full record

ArticleInternational journal of molecular sciences2024

Mechanistic Insight into the Enantioselective Degradation of Esterase QeH to (

Yu-Meng Zhu, Gui Yao, Song Shao, Xin-Yu Liu, Jun Xu, Chun Chen, Xing-Wang Zhang, Zhuo-Ran Huang, Cheng-Zhen Xu, Long Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yu-Meng ZhuAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Gui YaoAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Song ShaoAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Xin-Yu LiuAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Jun XuAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Chun ChenInstitute of Biomedicine, Jinan University, Guangzhou 510632, China.
Xing-Wang ZhangAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Zhuo-Ran HuangAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Cheng-Zhen XuAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Long ZhangAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.
Xiao-Min WuAnhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation, College of Life Sciences, Huaibei Normal University, Huaibei 235000, China.ORCID 0000-0002-0627-5414

Funding

Anhui College Students' Innovation and Entrepreneurship Training Program Molecular Dynam-ics Studies on the Enantioselective Degradation of QeH to (R)/(S)-Quizalofop-ethylNational Natural Science Foundation of China 31500594the Natural Science Foundation of Anhui Province 2208085MC65the Outstanding Youth Project of Natural Science Research in Colleges and Universities of Anhui Province 2023AH030077
6 · The paper itself

Abstract

The enantioselective mechanism of the esterase QeH against the two enantiomers of quizalofop-ethyl (QE) has been primitively studied using computational and experimental approaches. However, it is still unclear how the esterase QeH adjusts its conformation to adapt to substrate binding and promote enzym

Indexed as

EsterasesMolecular Dynamics SimulationCatalytic DomainKineticsStereoisomerismSubstrate SpecificityEsterasescatalytic kinetics characterizationenantioselective degradation mechanisminter-residue interactionmolecular dynamics simulationquizalofop–ethyl

Identifiers

PMID39337452
PMCPMC11432306

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.