Evidence map›Paper›PMID 39337434›Full record

ArticleInternational journal of molecular sciences2024

Novel Function of Osteocalcin in Chondrocyte Differentiation and Endochondral Ossification Revealed on a CRISPR/Cas9

Xiang-Fang Yu, Bin Teng, Jun-Feng Li, Jian V Zhang, Zhe Su, Pei-Gen Ren

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiang-Fang YuDepartment of Endocrinology, Shenzhen Children's Hospital, Shenzhen 518026, China.ORCID 0000-0003-2390-8567
Bin TengCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Jun-Feng LiCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Jian V ZhangCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Zhe SuDepartment of Endocrinology, Shenzhen Children's Hospital, Shenzhen 518026, China.ORCID 0000-0003-4101-8429
Pei-Gen RenShenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen 518055, China.ORCID 0000-0002-6477-9055

Funding

Guangdong Basic and Applied Basic Research Foundation 2024A1515013017Guangdong High-level Hospital Construction Fund and Guangdong High-level Hospital Construction Fund Clinical Research Project of Shenzhen Children's Hospital LCYJ2022071High-level Key Clinical Specialty project of Guangdong Provincial Health Commission (Supporting construction funds of Shenzhen) SZGSP012National Key R&D Program of China 2021YFA0719303National Natural Science Foundation of China 32100572National Natural Science Foundation of China 32271166Shenzhen Science and Technology Program JCYJ20200109115441918Shenzhen Science and Technology Program JCYJ20210324102013035
6 · The paper itself

Abstract

Endochondral ossification is the process by which cartilage is mineralized into bone, and is essential for the development of long bones. Osteocalcin (OCN), a protein abundant in bone matrix, also exhibits high expression in chondrocytes, especially hypertrophic chondrocytes, while its role in endochondral ossification remains unclear. Utilizing a new CRISPR/Cas9-mediated

Indexed as

Cell DifferentiationChondrocytesChondrogenesisCRISPR-Cas SystemsOsteocalcinOsteogenesisAnimalsCartilageMesenchymal Stem CellsMiceMice, KnockoutSignal TransductionBglap2 protein, mouseBGLAP protein, humanBglap protein, mouseOsteocalcincartilagechondrocyte differentiationendochondral ossificationosteocalcin

Identifiers

PMID39337434
PMCPMC11431882

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.