Evidence map›Paper›PMID 39337431›Full record

ArticleInternational journal of molecular sciences2024

Involvement of Aryl Hydrocarbon Receptor in Longevity and Healthspan: Insights from Humans, Mice, and

Eva Serna, David Verdú, Alicia Valls, Ángel Belenguer-Varea, Francisco José Tarazona-Santabalbina, Consuelo Borrás, José Viña

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eva SernaDepartment of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.ORCID 0000-0002-2968-3349
David VerdúDepartment of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.
Alicia VallsDepartment of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.ORCID 0000-0001-5653-9409
Ángel Belenguer-VareaDivision of Geriatrics, Hospital Universitario de La Ribera, 46600 Valencia, Spain.ORCID 0000-0002-0518-6612
Francisco José Tarazona-SantabalbinaDivision of Geriatrics, Hospital Universitario de La Ribera, 46600 Valencia, Spain.ORCID 0000-0003-4531-1446
Consuelo BorrásDepartment of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.ORCID 0000-0003-4606-1792
José ViñaDepartment of Physiology, School of Medicine, University of Valencia, CIBERFES, INCLIVA, 46010 Valencia, Spain.ORCID 0000-0001-9709-0089

Funding

Spanish Ministry of Innovation PID2019-110906RB-I00/AEI/10.13039/501100011033
6 · The paper itself

Abstract

In previous studies, using transcriptomic analysis, we observed higher levels of aryl hydrocarbon receptor (AHR) gene expression in the peripheral blood cells of centenarians compared to octogenarians. This suggests the potential significance of this receptor in maintaining physiological balance and promoting healthy aging, possibly linked to its critical role in detoxifying xenobiotics. In our current study, we confirmed that AHR expression is indeed higher in centenarians. We employed

Indexed as

Caenorhabditis elegansLongevityReceptors, Aryl HydrocarbonAged, 80 and overAnimalsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsFemaleHumansMaleMicePlant ExtractsPomegranateahr-1 protein, C elegansAHR protein, humanAhr protein, mouseBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsPlant ExtractsReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorlifespanpomegranate extractvitality

Identifiers

PMID39337431
PMCPMC11432571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.