Evidence map›Paper›PMID 39337430›Full record

ArticleInternational journal of molecular sciences2024

VEGF, but Not BDNF, Prevents the Downregulation of KCC2 Induced by Axotomy in Extraocular Motoneurons.

Jaime Capilla-López, Rosendo G Hernández, Génova Carrero-Rojas, Paula M Calvo, Francisco J Alvarez, Rosa R de la Cruz, Angel M Pastor

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jaime Capilla-LópezDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.
Rosendo G HernándezDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.ORCID 0000-0001-7098-8630
Génova Carrero-RojasCenter for Anatomy and Cell Biology, Division of Anatomy, Medical University Vienna, 1090 Vienna, Austria.ORCID 0000-0002-1984-3505
Paula M CalvoDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.
Francisco J AlvarezDepartment of Cell Biology, Emory University, Atlanta, GA 30322, USA.ORCID 0000-0001-7011-3244
Rosa R de la CruzDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.ORCID 0000-0001-5301-5108
Angel M PastorDepartamento de Fisiología, Facultad de Biología, Universidad de Sevilla, 41012 Sevilla, Spain.ORCID 0000-0002-6213-7454

Funding

Neuroinflammation Grading and Adjusting of Spinal Sensorimotor Circuitries in Response to Remote Injuries in Peripheral Nerves R01NS111969 · NINDS · EMORY UNIVERSITY · PI ALVAREZ, FRANCISCO J · 2020 to 2023
$1.5M
Inhibitory synapses and axon regeneration in adults after injury-induced axotomyR21NS114839 · NINDS · EMORY UNIVERSITY · PI ALVAREZ, FRANCISCO J, ENGLISH, ARTHUR W. · 2019 to 2020
$429k
MCIN, AEI, and European Union "Next Generation EU/Recovery, Transformation and Resilience Plan". RYC2021-033058-IMICIU/AEI/10.13039/501100011033/ FEDER PID2021-124300NBI00NINDS NIH HHS R01 NS111969NINDS NIH HHS R21 NS114839
6 · The paper itself

Abstract

The potassium-chloride cotransporter KCC2 is the main extruder of Cl

Indexed as

AxotomyBrain-Derived Neurotrophic FactorK Cl- CotransportersMotor NeuronsSymportersVascular Endothelial Growth Factor AAnimalsDown-RegulationMaleRatsRats, WistarBdnf protein, ratBrain-Derived Neurotrophic FactorK Cl- CotransportersSymportersVascular Endothelial Growth Factor Abrain-derived neurotrophic factorcation–chloride cotransporterschloride homeostasischoline acetyltransferase (ChAT)GABA depolarizationnerve injuryneurological diseasesNKCC1oculomotor systemvascular endothelial growth factor

Identifiers

PMID39337430
PMCPMC11432591

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.