Evidence map›Paper›PMID 39337269›Full record

ArticleInternational journal of molecular sciences2024

Comparison of Mitochondrial and Antineoplastic Effects of Amiodarone and Desethylamiodarone in MDA-MB-231 Cancer Line.

Fadi H J Ramadan, Balazs Koszegi, Viola B Vantus, Katalin Fekete, Gyongyi N Kiss, Balint Rizsanyi, Rita Bognar, Ferenc Gallyas, Zita Bognar

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fadi H J RamadanDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0000-0003-3910-1725
Balazs KoszegiDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0000-0001-6743-0441
Viola B VantusDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0000-0001-7557-3004
Katalin FeketeDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Gyongyi N KissDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0009-0001-5266-4453
Balint RizsanyiDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Rita BognarDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Ferenc GallyasDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0000-0002-1906-4333
Zita BognarDepartment of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.ORCID 0000-0003-0582-7755

Funding

János Bolyai Research Scholarship of the Hungarian Academy of Sciences bo_215_21Ministry for Innovation and Technology EFOP-3.6.1-16-2016-00004Ministry for Innovation and Technology GINOP-2.3.2-15-2016-00049Ministry for Innovation and Technology GINOP-2.3.3-15-2016-00025Ministry for Innovation and Technology TKP2021-EGA-17Ministry for Innovation and Technology ÚNKP-23-5University of Pecs Medical School ÁOK KA-2022-10
6 · The paper itself

Abstract

Previously, we have demonstrated that amiodarone (AM), a widely used antiarrhythmic drug, and its major metabolite desethylamiodarone (DEA) both affect several mitochondrial processes in isolated heart and liver mitochondria. Also, we have established DEA's antitumor properties in various cancer cell lines and in a rodent metastasis model. In the present study, we compared AM's and DEA's mitochondrial and antineoplastic effects in a human triple-negative breast cancer (TNBC) cell line. Both compounds reduced viability in monolayer and sphere cultures and the invasive growth of the MDA-MB-231 TNBC line by inducing apoptosis. They lowered mitochondrial trans-membrane potential, increased Ca

Indexed as

AmiodaroneAntineoplastic AgentsApoptosisMitochondriaTriple Negative Breast NeoplasmsAdenosine TriphosphateCalciumCell Line, TumorCell ProliferationCell SurvivalFemaleHumansMembrane Potential, MitochondrialAdenosine TriphosphateAmiodaroneAntineoplastic AgentsCalciumdesethylamiodaroneapoptosiscancer cell energy metabolismdrug repositioningmitochondrial drugmitochondrial dysfunction

Identifiers

PMID39337269
PMCPMC11432025

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.