Evidence map›Paper›PMID 39337254›Full record

ArticleInternational journal of molecular sciences2024

Neutrophil Extracellular Traps Affect Human Inner Ear Vascular Permeability.

Marijana Sekulic, Stavros Giaglis, Nina Chatelain, Daniel Bodmer, Vesna Petkovic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marijana SekulicDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.ORCID 0000-0002-3761-7253
Stavros GiaglisDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.ORCID 0000-0003-2216-9539
Nina ChatelainDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
Daniel BodmerDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
Vesna PetkovicDepartment of Biomedicine, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.ORCID 0000-0002-0741-9774

Funding

Animalfree Research, Bern, Switzerland. 00001
6 · The paper itself

Abstract

The integrity of the blood-labyrinth barrier (BLB) is essential for inner ear homeostasis, regulating the ionic composition of endolymph and perilymph and preventing harmful substance entry. Endothelial hyperpermeability, central in inflammatory and immune responses, is managed through complex intercellular communication and molecular signaling pathways. Recent studies link BLB permeability dysregulation to auditory pathologies like acoustic trauma, autoimmune inner ear diseases, and presbycusis. Polymorphonuclear granulocytes (PMNs), or neutrophils, significantly modulate vascular permeability, impacting endothelial barrier properties. Neutrophil extracellular traps (NETs) are involved in diseases with autoimmune and autoinflammatory bases. The present study evaluated the impact of NETs on a BLB cellular model using a Transwell

Indexed as

CadherinsCapillary PermeabilityEar, InnerEndothelial CellsExtracellular TrapsNeutrophilsAntigens, CDCadherin 5HumansOccludinZonula Occludens-1 ProteinAntigens, CDCadherin 5CadherinsOccludinOCLN protein, humanTJP1 protein, humanZonula Occludens-1 Proteinblood–labyrinth barrierhearing lossMeniere’s diseaseTEERtissue model

Identifiers

PMID39337254
PMCPMC11431685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.