Evidence map›Paper›PMID 39337075›Full record

ReviewJournal of clinical medicine2024

Electrocardiographic Patterns and Arrhythmias in Cardiac Amyloidosis: From Diagnosis to Therapeutic Management-A Narrative Review.

Lucio Teresi, Giancarlo Trimarchi, Paolo Liotta, Davide Restelli, Roberto Licordari, Gabriele Carciotto, Costa Francesco, Pasquale Crea, Giuseppe Dattilo, Antonio Micari and 3 more

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Cardiac Amyloidosis: Pathogenesis, Diagnosis, and Treatment.Deutsches Arzteblatt international · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.Heart views : the official journal of the Gulf Heart Association · 2026
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Amyloids and the Heart: An Update.Journal of clinical medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lucio TeresiDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.ORCID 0000-0001-5626-0336
Giancarlo TrimarchiDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.ORCID 0009-0008-9165-7732
Paolo LiottaDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Davide RestelliDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Roberto LicordariDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Gabriele CarciottoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.ORCID 0009-0007-8015-5211
Costa FrancescoDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Pasquale CreaDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.
Giuseppe DattiloDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.ORCID 0000-0002-6681-0183
Antonio MicariDepartment of Biomedical and Dental Sciences and Morphological and Functional Imaging, University of Messina, 98100 Messina, Italy.
Michele EmdinHealth Science Interdisciplinary Center, Scuola Superiore Sant'Anna, 56127 Pisa, Italy.
Antonio BerruezoHeart Institute, Teknon Medical Centre, 08022 Barcelona, Spain.
Gianluca Di BellaDepartment of Clinical and Experimental Medicine, University of Messina, 98100 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrophysiological aspects of cardiac amyloidosis (CA) are still poorly explored compared to other aspects of the disease. However, electrocardiogram (ECG) abnormalities play an important role in CA diagnosis and prognosis and the management of arrhythmias is a crucial part of CA treatment. Low voltages and a pseudonecrosis pattern with poor R-wave progression in precordial leads are especially common findings. These are useful for CA diagnosis and risk stratification, especially when combined with clinical or echocardiographic findings. Both ventricular and supraventricular arrhythmias are common in CA, especially in transthyretin amyloidosis (ATTR), and their prevalence is related to disease progression. Sustained and non-sustained ventricular tachycardias' prognostic role is still debated, and, to date, there is a lack of specific indications for implantable cardiac defibrillator (ICD). On the other hand, atrial fibrillation (AF) is the most common supraventricular arrhythmia with a prevalence of up to 88% of ATTR patients. Anticoagulation should be considered irrespective of CHADsVA score. Furthermore, even if AF seems to not be an independent prognostic factor in CA, its treatment for symptom control is still crucial. Finally, conduction disturbances and bradyarrhythmias are also common, requiring pacemaker implantation in up to 40% of patients.

Indexed as

arrhythmiascardiac amyloidosiselectrocardiogram

Identifiers

PMID39337075
PMCPMC11432666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.