Evidence map›Paper›PMID 39336984›Full record

ReviewJournal of clinical medicine2024

High-Intensity Exercise Training Impact on Cardiorespiratory Fitness, Gait Ability, and Balance in Stroke Survivors: A Systematic Review and Meta-Analysis.

Alessio Baricich, Margherita Beatrice Borg, Marco Battaglia, Salvatore Facciorusso, Stefania Spina, Marco Invernizzi, Lorenza Scotti, Lucia Cosenza, Alessandro Picelli, Andrea Santamato

Abstract readReview
In one paragraph

Review in Journal of clinical medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  16. Tailoring interval training in stroke rehabilitation: The role of peak velocity.Journal of rehabilitation research and practice · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessio BaricichDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.ORCID 0000-0001-8440-6283
Margherita Beatrice BorgDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0002-0831-4843
Marco BattagliaDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0003-1357-1374
Salvatore FacciorussoDepartment of Medical and Surgical Sciences, Spasticity and Movement Disorders "ReSTaRt" Unit, Physical Medicine and Rehabilitation Section, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0001-6748-9152
Stefania SpinaDepartment of Medical and Surgical Sciences, Spasticity and Movement Disorders "ReSTaRt" Unit, Physical Medicine and Rehabilitation Section, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-7220-4016
Marco InvernizziDepartment of Health Sciences, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.ORCID 0000-0001-5141-0681
Lorenza ScottiDepartment of Translational Medicine, Università del Piemonte Orientale "Amedeo Avogadro", 28100 Novara, Italy.
Lucia CosenzaPhysical Medicine and Rehabilitation Unit, AOU Maggiore della Carità University Hospital, 28100 Novara, Italy.
Alessandro PicelliDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37129 Verona, Italy.ORCID 0000-0002-3558-8276
Andrea SantamatoDepartment of Medical and Surgical Sciences, Spasticity and Movement Disorders "ReSTaRt" Unit, Physical Medicine and Rehabilitation Section, University of Foggia, 71122 Foggia, Italy.ORCID 0000-0002-1452-8485

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke survivors commonly face challenges such as reduced physical activity and cardiorespiratory fitness (CRF) as well as balance and gait impairments, exacerbating their disability. While high-intensity exercise interventions have demonstrated some potential, their effects on these items remain uncertain. Therefore, our study aimed to investigate the impact of high-intensity training protocols on CRF, gait ability, and balance in stroke survivor populations. Two independent investigators systematically searched five databases for relevant RCTs following the PICO model. Through a systematic review of 25 RCTs published up to 31 May 2023, including adult first-stroke survivors, comparing high-intensity exercise training versus low-to-mild or no exercises, we evaluated outcomes such as the Six-Minute Walking Test (6 MWT), peak oxygen uptake (VO2peak), Ten-Meter Walk Test (10 MWT), Berg Balance Scale (BBS), and Timed Up and Go test (TUG). The protocol was registered in PROSPERO (registration number CRD42023456773). Meta-analyses indicated significant enhancements in CRF, as measured by 6 MWT and VO2peak, following high-intensity exercise interventions. However, no significant differences were observed in BBS, 10 MWT, and TUG. Our findings underscore the potential of high-intensity exercise interventions in ameliorating CRF among stroke survivors, although further research involving standardized protocols and long-term follow-ups is imperative to optimize rehabilitation outcomes.

Indexed as

cardio-respiratory fitnesshigh-intensity exercisehigh-intensity trainingmeta-analysisrehabilitationstroke

Identifiers

PMID39336984
PMCPMC11432212

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.