Evidence map›Paper›PMID 39336795›Full record

ArticleGenes2024

CD33 and SHP-1/

Lien Beckers, Mamunur Rashid, Annie J Lee, Zena K Chatila, Kirstin A Tamucci, Ryan C Talcoff, Jennifer L Hall, David A Bennett, Badri N Vardarajan, Elizabeth M Bradshaw

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lien BeckersDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0003-4625-9811
Mamunur RashidDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0001-6768-1814
Annie J LeeDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Zena K ChatilaDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Kirstin A TamucciDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-7033-807X
Ryan C TalcoffDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jennifer L HallDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
David A BennettRush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.
Badri N VardarajanDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Elizabeth M BradshawDepartment of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.ORCID 0000-0002-6766-4325

Funding

The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI LEIGH A JOHNSON · 2022 to 2026
$181.1M
Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ADAM M BRICKMAN · 2020 to 2026
$30.1M
Training in Translational Immunology ResearchT32AI148099 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2020 to 2024
$1.4M
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377k
NIAID NIH HHS T32 AI148099NIA NIH HHS K01 AG084849NIA NIH HHS P30 AG066462NIA NIH HHS U19 AG078109NIH HHS P30AG066462; RF1AG058852;R01AG043617;F30AG074618;T32AI148099; P30AG10161, P30AG72975; R01AG15819; R01AG17917; U01AG46152; and U01AG61356
6 · The paper itself

Abstract

Large-scale genetic studies have identified numerous genetic risk factors that suggest a central role for innate immune cells in susceptibility to Alzheimer's disease (AD). CD33, an immunomodulatory transmembrane sialic acid binding protein expressed on myeloid cells, was identified as one such genetic risk factor associated with Alzheimer's disease. Several studies explored the molecular outcomes of genetic variation at the

Indexed as

Alzheimer DiseaseProtein Tyrosine Phosphatase, Non-Receptor Type 6Sialic Acid Binding Ig-like Lectin 3Genetic Predisposition to DiseaseHumansMicrogliaPolymorphism, Single NucleotideCD33 protein, humanProtein Tyrosine Phosphatase, Non-Receptor Type 6PTPN6 protein, humanSialic Acid Binding Ig-like Lectin 3Alzheimer’s diseaseCD33microgliaSHP-1

Identifiers

PMID39336795
PMCPMC11431297

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.