Evidence map›Paper›PMID 39336750›Full record

ArticleGenes2024

Positive Selection Drives the Evolution of the Structural Maintenance of Chromosomes (SMC) Complexes.

Diego Forni, Alessandra Mozzi, Manuela Sironi, Rachele Cagliani

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Cross-species incompatibilities offer new insights into the functional consequences of satellite DNA evolution.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026
    Review
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Diego ForniComputational Biology Unit, Scientific Institute IRCCS E. MEDEA, 23842 Bosisio Parini, Italy.ORCID 0000-0001-9291-5352
Alessandra MozziComputational Biology Unit, Scientific Institute IRCCS E. MEDEA, 23842 Bosisio Parini, Italy.ORCID 0000-0003-3911-1042
Manuela SironiComputational Biology Unit, Scientific Institute IRCCS E. MEDEA, 23842 Bosisio Parini, Italy.ORCID 0000-0002-2267-5266
Rachele CaglianiComputational Biology Unit, Scientific Institute IRCCS E. MEDEA, 23842 Bosisio Parini, Italy.ORCID 0000-0003-2670-3532

Funding

Ministero della Salute Ricerca Corrente
6 · The paper itself

Abstract

Structural Maintenance of Chromosomes (SMC) complexes are an evolutionary conserved protein family. In most eukaryotes, three SMC complexes have been characterized, as follows: cohesin, condensin, and SMC5/6 complexes. These complexes are involved in a plethora of functions, and defects in SMC genes can lead to an increased risk of chromosomal abnormalities, infertility, and cancer. To investigate the evolution of SMC complex genes in mammals, we analyzed their selective patterns in an extended phylogeny. Signals of positive selection were identified for condensin NCAPG, for two SMC5/6 complex genes (

Indexed as

Adenosine TriphosphatasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinsDNA-Binding ProteinsEvolution, MolecularMultiprotein ComplexesSelection, GeneticAnimalsHumansMeiosisPhylogenyAdenosine TriphosphatasesCell Cycle ProteinsChromosomal Proteins, Non-HistoneCohesinscondensin complexesDNA-Binding ProteinsMultiprotein Complexeshost-pathogen arms raceintragenomic conflictmeiotic cohesinspositive selectionstructural maintenance of chromosomes

Identifiers

PMID39336750
PMCPMC11431564

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.