Evidence map›Paper›PMID 39336709›Full record

ArticleGenes2024

Impact of NSD1 Alternative Transcripts in Actin Filament Formation and Cellular Division Pathways in Fibroblasts.

Giuseppina Conteduca, Davide Cangelosi, Chiara Baldo, Alessia Arado, Barbara Testa, Ryan T Wagner, Keith D Robertson, Franck Dequiedt, Lane Fitzsimmons, Michela Malacarne and 2 more

Abstract read
In one paragraph

Article in Genes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Giuseppina ConteducaBiotherapy Unit, IRCCS San Martino, 16132 Genoa, Italy.ORCID 0000-0003-4301-3576
Davide CangelosiClinical Bioinformatics Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Chiara BaldoLaboratory of Human Genetics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-7508-3953
Alessia AradoLaboratory of Human Genetics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Barbara TestaLaboratory of Human Genetics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Ryan T WagnerDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6725-2064
Keith D RobertsonDepartment of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-7508-3328
Franck DequiedtGIGA-Molecular Biology of Diseases Laboratory of Gene Expression and Cancer, University of Liege, 4000 Liège, Belgium.ORCID 0000-0003-1234-7477
Lane FitzsimmonsRenaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Michela MalacarneLaboratory of Human Genetics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Gilberto FilaciBiotherapy Unit, IRCCS San Martino, 16132 Genoa, Italy.ORCID 0000-0001-6445-8414
Domenico A CovielloLaboratory of Human Genetics, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.ORCID 0000-0001-8440-865X

Funding

AssiGulliver association AssiGulliver association 2023Bank of Italy 2022Fondazione Sardegna Fondazione Sardegna 2022Ministero della Salute 5xmille Gaslini 5M-2020-23682542Ministero della Salute Ricerca corrente Gaslini 2023
6 · The paper itself

Abstract

Germline variants in the NSD1 gene are responsible for Sotos syndrome, while somatic variants promote neoplastic cell transformation. Our previous studies revealed three alternative RNA isoforms of

Indexed as

Actin CytoskeletonFibroblastsHistone-Lysine N-MethyltransferaseProtein IsoformsAlternative SplicingCell DivisionCell LineHumansStress FibersHistone-Lysine N-MethyltransferaseNSD1 protein, humanProtein Isoformscell cyclecytoskeletonisoformsneoplastic pathwaysNSD1

Identifiers

PMID39336709
PMCPMC11431170

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.