Evidence map›Paper›PMID 39336548›Full record

ReviewMedicina (Kaunas, Lithuania)2024

Novel Models for Assessing and Pathophysiology of Hepatic Ischemia-Reperfusion Injury Mechanisms.

Connor Whalen, Arun Verma, Kento Kurashima, Jasmine Carter, Hala Nazzal, Ajay Jain

Abstract readReview
In one paragraph

Review in Medicina (Kaunas, Lithuania), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
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  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Connor WhalenDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.ORCID 0009-0003-3768-8531
Arun VermaDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.ORCID 0000-0001-9374-4823
Kento KurashimaDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.ORCID 0000-0002-3614-2559
Jasmine CarterDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.
Hala NazzalDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.
Ajay JainDepartment of Pediatrics, St. Louis University School of Medicine, St. Louis, MO 63104, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury (IRI) is a major cause of postoperative hepatic dysfunction and liver failure involving cellular damage to previously ischemic tissues to which blood flow is restored. The reestablishment of blood flow is essential for salvaging ischemic tissues. The reperfusion itself, however, can paradoxically lead to further cellular damage, which involves a multi-factorial process resulting in extensive tissue damage, which can threaten the function and viability of the liver and other organ systems. The following review outlines multiple models for in-lab analysis of the various hepatic IRI mechanisms, including murine, porcine, cell lines, and machine perfusion models.

Indexed as

Disease Models, AnimalLiverReperfusion InjuryAnimalsHumansMiceSwinecell lineischemia–reperfusion injurymachine perfusionmurineporcinereactive oxygen species

Identifiers

PMID39336548
PMCPMC11434406

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.