Evidence map›Paper›PMID 39335635›Full record

ArticleBiomedicines2024

Exploring the Antibacterial and Regenerative Properties of a Two-Stage Alginate Wound Dressing in a Rat Model of Purulent Wounds.

Aliya Atepileva, Vyacheslav Ogay, Gulshahar Kudaibergen, Guldarigash Kaukabaeva, Assiya Nurkina, Ainur Mukhambetova, Serik Balgazarov, Arman Batpen, Dina Saginova, Zhanatay Ramazanov and 2 more

Abstract read
In one paragraph

Article in Biomedicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aliya AtepilevaDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.
Vyacheslav OgayStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0001-5029-5255
Gulshahar KudaibergenStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-0779-4099
Guldarigash KaukabaevaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Assiya NurkinaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.
Ainur MukhambetovaStem Cell Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0009-0007-8091-3449
Serik BalgazarovDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.
Arman BatpenDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.
Dina SaginovaDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.ORCID 0000-0001-9551-5354
Zhanatay RamazanovDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.
Amanzhol BalgazarovDepartment of Traumatology No. 4, National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, Astana 010000, Kazakhstan.
Zhanar AkhmetkarimovaToxicology and Pharmacology Laboratory, National Center for Biotechnology, Astana 010000, Kazakhstan.ORCID 0000-0002-9782-5521

Funding

Ministry of Education and Science of the Republic of Kazakhstan АР13068136
6 · The paper itself

Abstract

Chronic wounds complicated by infection pose significant clinical challenges, necessitating comprehensive treatment approaches. The widespread use of antibiotics has led to resistant microorganisms, complicating traditional therapies. This study aims to develop and evaluate modified alginate wound dressings with enhanced antimicrobial and regenerative properties. Alginate dressings were synthesized with silver nanoparticles, cefepime, and fibroblast growth factor-2 (FGF-2). The two-stage therapy involved an initial antibacterial dressing followed by a regenerative dressing. In vitro tests demonstrated high antibacterial activity, with maximum inhibition zones for

Indexed as

alginate wound dressingsantibacterial propertiescefepimechronic woundsFGF-2regenerative medicinesilver nanoparticles

Identifiers

PMID39335635
PMCPMC11430427

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.