Evidence map›Paper›PMID 39335357›Full record

ArticleBrain sciences2024

The Neuroprotective and Anxiolytic Effects of Magnesium Sulfate on Retinal Dopaminergic Neurons in 6-OHDA-Induced Parkinsonian Rats: A Pilot Study.

Leyi Huang, Renxi Lin, Chunying Zhang, Shaoqing Zheng, Yiyang Wang, Zeyu Wu, Sihao Chen, Yihan Shen, Guoheng Zhang, Yuanlin Qi and 1 more

Abstract read
In one paragraph

Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Leyi HuangDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.ORCID 0000-0003-2993-570X
Renxi LinDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.ORCID 0000-0002-8316-8364
Chunying ZhangDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.
Shaoqing ZhengSchool of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China.
Yiyang WangSchool of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China.
Zeyu WuSchool of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China.
Sihao ChenSchool of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China.
Yihan ShenSchool of Clinical Medicine, Fujian Medical University, Fuzhou 350122, China.
Guoheng ZhangDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.
Yuanlin QiDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.ORCID 0000-0002-5253-9732
Ling LinDepartment of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the protective effects of magnesium sulfate on dopamine neurons in the retinas of rats with 6-hydroxydopamine (6-OHDA)-induced Parkinson's disease (PD). Rapidly progressing cognitive decline often precedes or coincides with the motor symptoms associated with PD. PD patients also frequently exhibit visual function abnormalities. However, the specific mechanisms underlying visual dysfunction in PD patients are not yet fully understood. Therefore, this study aims to investigate whether magnesium homeostasis affects dopaminergic neurons in the retina of PD rats. Thirty-six rats were divided into four groups: (1) control, (2) control with magnesium sulfate (control/MgSO

Indexed as

magnesium ionmagnesium ion transporterParkinson’s diseaseretinatyrosine hydroxylase

Identifiers

PMID39335357
PMCPMC11430011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.