Evidence map›Paper›PMID 39335211›Full record

ArticleCancers2024

Unique Gene Expression Profiles within South Africa Are Associated with Varied Chemotherapeutic Responses in Conventional Osteosarcoma.

Phakamani G Mthethwa, Thilona Arumugam, Veron Ramsuran, Anmol Gokul, Reitze Rodseth, Leonard Marais

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Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Phakamani G MthethwaDr Pixley Ka Isaka Seme Memorial Hospital, University of KwaZulu-Natal, Nelson Mandela School of Clinical Medicine, 310 Bhejane Street, KwaMashu, Durban 4360, South Africa.
Thilona ArumugamCentre for the AIDS Programme of Research in South Africa (CAPRISA), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.
Veron RamsuranCentre for the AIDS Programme of Research in South Africa (CAPRISA), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0003-1590-9893
Anmol GokulCentre for the AIDS Programme of Research in South Africa (CAPRISA), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa.ORCID 0000-0002-4509-726X
Reitze RodsethNelson Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.ORCID 0000-0002-3779-7805
Leonard MaraisNelson Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal, 719 Umbilo Road, Durban 4001, South Africa.ORCID 0000-0002-1120-8419

Funding

Discovery Foundation 049492
6 · The paper itself

Abstract

backgroundWe determined the predictive gene expression profiles associated with chemo-response in conventional osteosarcomas (COS) within South Africa. MATERIALS AND

methodsIn 28 patients, we performed an RNA extraction, cDNA synthesis, and quantitative analysis using the RT-PCR 2

resultsWe observed a significant downregulation in the mRNA expression profiles of

conclusionsIn this South African cohort, we observed the unique gene expression profiles of osteosarcoma tumourigenesis and chemotherapeutic responses. These may serve as prognostication and therapeutic targets. Larger-scale research is needed on the African continent.

Indexed as

chemotherapy responsegene expression profilesosteosarcoma

Identifiers

PMID39335211
PMCPMC11429586

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