The Phenotypical Characterization of Dual-Nature Hybrid Cells in Uveal Melanoma.

Emily Marcotte, Alicia Goyeneche, Mohamed Abdouh, Julia Valdemarin Burnier, Miguel Noel Burnier

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In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Emily MarcotteCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.ORCID 0009-0002-8648-7093

Alicia GoyenecheCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Mohamed AbdouhCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Julia Valdemarin BurnierCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Miguel Noel BurnierCancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC H4A 3J1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMetastasis, occurring years after primary diagnosis, represents a poor prognosis in uveal melanoma (UM)-affected individuals. The nature of cells involved in this process is under debate. Circulating hybrid cells that have combined tumor and immune cell features found in blood were predictive of metastasis and may correspond to dual-nature cells (DNC) in the primary tumor. Herein, we sought to determine the presence of DNCs in primary UM tumors, the cell types involved in their genesis, and their ability to be formed in vitro.

methodsUM lesions (n = 38) were immunolabeled with HMB45 in combination with immune-cell-specific antibodies. In parallel, we co-cultured UM cells and peripheral blood mononuclear cells (PBMCs) to analyze DNC formation.

resultsHMB45

conclusionsThis phenotypical characterization of DNCs in UM demonstrates that CD8

Indexed as

cell–cell fusioncell co-culturecirculating hybrid cellsdual-nature hybrid cellsimmunophenotypingprimary tumorsuveal melanoma

Identifiers

PMID39335202

DOI10.3390/cancers16183231

PMCPMC11429545

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