Evidence map›Paper›PMID 39335115›Full record

ArticleCancers2024

Local Invasion Patterns Characterized by SARIFA and Tumor Budding Differ and Have Distinct Prognostic Significance in Esophageal Adenocarcinoma and Squamous Cell Carcinoma.

Ákos Jakab, Levente Zarándy, Ildikó Kocsmár, Tibor Várkonyi, István Kenessey, Attila Szijártó, András Kiss, Tamás Vass, Gábor Lotz, Éva Kocsmár

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ákos JakabDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.
Levente ZarándyDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.
Ildikó KocsmárDepartment of Urology, Semmelweis University, Üllői Str. 78/b, H-1082 Budapest, Hungary.
Tibor VárkonyiDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.
István KenesseyDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.ORCID 0000-0002-6963-8489
Attila SzijártóDepartment of Surgery, Transplantation and Gastroenterology, Semmelweis University, Üllői Str. 78, H-1082 Budapest, Hungary.
András KissDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.ORCID 0000-0002-7453-3163
Tamás VassDepartment of Surgery, Transplantation and Gastroenterology, Semmelweis University, Üllői Str. 78, H-1082 Budapest, Hungary.ORCID 0000-0001-9078-5558
Gábor LotzDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.ORCID 0000-0002-6921-8978
Éva KocsmárDepartment of Pathology, Forensic and Insurance Medicine, Semmelweis University, Üllői Str. 93, H-1091 Budapest, Hungary.ORCID 0000-0003-3061-1323

Funding

Ministry for Culture and Innovation ÚNKP-23-4-II-SE-24National Research, Development and Innovation Office K_22 142604
6 · The paper itself

Abstract

Both esophageal squamous cell carcinoma (ESQCC) and adenocarcinoma (EAC) are known to have poor prognosis. We aimed to investigate the invasion front areas of 57 ESQCC and 43 EAC cases to find histological signs of metastatic progression. Tumor cell clusters with different cell counts, including tumor buds (TBs) and poorly differentiated clusters (PDCs), were assessed. The presence of the recently described Stroma AReactive Invasion Front Area (SARIFA) phenomenon, which defines a direct contact between tumor cells and adipocytes, was more frequently observed in EAC than in ESQCC (

Indexed as

esophageal adenocarcinomaesophageal canceresophageal squamous cell carcinomainvasion frontpoorly differentiated clustersSARIFAtumor budding

Identifiers

PMID39335115
PMCPMC11430286

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.