Evidence map›Paper›PMID 39335008›Full record

ReviewAntibiotics (Basel, Switzerland)2024

Innovative Strategies in Drug Repurposing to Tackle Intracellular Bacterial Pathogens.

Blanca Lorente-Torres, Jesús Llano-Verdeja, Pablo Castañera, Helena Á Ferrero, Sergio Fernández-Martínez, Farzaneh Javadimarand, Luis M Mateos, Michal Letek, Álvaro Mourenza

Abstract readReview
In one paragraph

Review in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Revisiting the Fight AgainstAntibiotics (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Frontiers in cellular and infection microbiology · 2026
    Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Blanca Lorente-TorresDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0000-0003-0131-7520
Jesús Llano-VerdejaDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0009-0007-3238-5565
Pablo CastañeraDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0009-0008-4314-4457
Helena Á FerreroDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0009-0003-1582-2779
Sergio Fernández-MartínezDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0009-0001-9642-9850
Farzaneh JavadimarandDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.
Luis M MateosDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0000-0001-7763-582X
Michal LetekDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0000-0002-9509-5174
Álvaro MourenzaDepartamento de Biología Molecular, Área de Microbiología, Universidad de León, 24071 León, Spain.ORCID 0000-0003-4926-3891

Funding

Junta de Castilla y León LE044P20MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR CNS2022-135378
6 · The paper itself

Abstract

Intracellular bacterial pathogens pose significant public health challenges due to their ability to evade immune defenses and conventional antibiotics. Drug repurposing has recently been explored as a strategy to discover new therapeutic uses for established drugs to combat these infections. Utilizing high-throughput screening, bioinformatics, and systems biology, several existing drugs have been identified with potential efficacy against intracellular bacteria. For instance, neuroleptic agents like thioridazine and antipsychotic drugs such as chlorpromazine have shown effectiveness against

Indexed as

antimicrobial resistancedrug repurposing/drug repositioninghigh-throughput screeninghost-directed therapyintracellular bacterial pathogensmultidrug resistance

Identifiers

PMID39335008
PMCPMC11428606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.