Evidence map›Paper›PMID 39334916›Full record

ArticleBiomolecules2024

HLA-Cw6 Polymorphism in Autoimmune Blistering Diseases.

Christian Ciolfi, Alvise Sernicola, Mauro Alaibac

Abstract read
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Christian CiolfiDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.ORCID 0000-0002-9098-4124
Alvise SernicolaDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.ORCID 0000-0002-1985-0326
Mauro AlaibacDermatology Unit, Department of Medicine (DIMED), University of Padua, 35121 Padova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune blistering diseases of the pemphigus and pemphigoid groups are immune-mediated disorders due to circulating pathogenetic autoantibodies. Multiple human leukocyte antigen (HLA) genes have been associated with predisposition to these disorders. HLA-Cw6 is involved in antigen presentation processes and has been linked to psoriasis. The aim of our study was to investigate the association between the presence of the HLA-Cw6 allele and susceptibility to pemphigus vulgaris and bullous pemphigoid. A genetic study in vitro with a cross-sectional design was performed enrolling forty patients with pemphigus vulgaris and forty patients with bullous pemphigoid. The detection of HLA-Cw6 was performed through the EUROArray test on DNA obtained from whole blood samples. The polymorphism was detected in 3/40 genotypes in the pemphigus vulgaris group and in 4/40 genotypes of patients with bullous pemphigoid, unveiling a non-statistically significant different frequency in pemphigus (

Indexed as

Genetic Predisposition to DiseaseHLA-C AntigensPemphigoid, BullousPemphigusAdultAgedAllelesAutoimmune DiseasesCross-Sectional StudiesFemaleGene FrequencyGenotypeHumansMaleMiddle AgedPolymorphism, GeneticHLA-C*06 antigenHLA-C Antigensautoimmune blistering diseasesbullous pemphigoidgenotypingHLA-Cw6pemphigus vulgarispolymorphism

Identifiers

PMID39334916
PMCPMC11430710

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.