Evidence map›Paper›PMID 39334893›Full record

ArticleBiomolecules2024

Oxylipins in Aqueous Humor of Primary Open-Angle Glaucoma Patients.

Jianming Xu, Kewen Zhou, Changzhen Fu, Chong-Bo Chen, Yaru Sun, Xin Wen, Luxi Yang, Tsz-Kin Ng, Qingping Liu, Mingzhi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jianming XuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.ORCID 0000-0002-8231-7858
Kewen ZhouJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Changzhen FuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.ORCID 0000-0002-3320-6262
Chong-Bo ChenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.ORCID 0000-0003-1421-4109
Yaru SunJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Xin WenJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Luxi YangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Tsz-Kin NgJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Qingping LiuJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.
Mingzhi ZhangJoint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong, Shantou 515041, China.

Funding

National Natural Science Foundation of China 82171044Natural Science Foundation of Guangdong Province 2022A1515011646
6 · The paper itself

Abstract

purposeInvestigate the oxylipin profiles in the aqueous humor of primary open-angle glaucoma (POAG) patients.

methodsAqueous humor samples were collected from 17 POAG patients and 15 cataract subjects and subjected to a liquid chromatography/mass spectrometry (LC-MS) analysis to detect the oxylipins. The prediction potential of the differential abundant oxylipins was assessed by the receiver operating characteristic (ROC) curves. Pathway and correlation analyses on the oxylipins and clinical and biochemical parameters were also conducted.

resultsThe LC-MS analysis detected a total of 76 oxylipins, of which 29 oxylipins reached the detection limit. The multivariate analysis identified five differential abundant oxylipins, 15-keto-prostaglandin F2 alpha (15-kPGF2α), Leukotriene B4 (LTB4), 12,13-Epoxyoctadecenoic acid (12,13-Epome), 15-Hydroxyeicosatetraenoic acid (15-HETE) and 11-Hydroxyeicosatetraenoic acid (11-HETE). The five oxylipins are enriched in the arachidonic acid metabolism and linoleic acid metabolism pathways. Pearson correlation analysis showed that 11-HETE was positively correlated with intraocular pressure and central corneal thickness and negatively with cup/disk area ratio in the POAG patients. In addition, 15-kPGF2α was moderately and positively correlated with the mean deviation (MD) of visual field defect, and LTB4 was moderately and negatively correlated with macular thickness.

conclusionsThis study revealed the oxylipin profile in the aqueous humor of POAG patients. Oxylipins involved in the arachidonic acid metabolism pathway could play a role in POAG, and anti-inflammatory therapies could be potential treatment strategies for POAG.

Indexed as

Aqueous HumorGlaucoma, Open-AngleOxylipinsAgedChromatography, LiquidFemaleHumansIntraocular PressureMaleMiddle AgedOxylipinsaqueous humorarachidonic acidoxylipinsprimary open-angle glaucoma

Identifiers

PMID39334893
PMCPMC11430124

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