Evidence map›Paper›PMID 39334816›Full record

ArticleBiomolecules2024

Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events.

Noelia Rísquez Chica, Elisa Pereira, Francisco Manzano, María Mar Jiménez Quintana, Antonio Osuna, María Carmen Ruiz Fuentes, Rosemary Wangensteen

Abstract read
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In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noelia Rísquez ChicaNephrology Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
Elisa PereiraNephrology Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
Francisco ManzanoIntensive Care Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
María Mar Jiménez QuintanaIntensive Care Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
Antonio OsunaNephrology Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
María Carmen Ruiz FuentesNephrology Unit, Virgen de las Nieves University Hospital, FIBAO, Instituto de Investigación Biosanitaria ibs, 18014 Granada, Spain.
Rosemary WangensteenArea of Physiology, Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.ORCID 0000-0001-7161-9925

Funding

Instituto de Salud Carlos III PI18/01715Instituto de Salud Carlos III RD21/0005/0015
6 · The paper itself

Abstract

backgroundDiagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers of cardiac surgery-associated AKI (CSA-AKI).

methodsGlutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), dipeptidyl peptidase-4 (DPP4), proteinuria, albuminuria, N-acetyl-β-

resultsGluAp diagnosed the maximal number of patients that developed stage 2 or 3 of AKI, increasing diagnostic sensitivity from 0% to 75%. In addition, GluAp and DPP4 were related to the decrease in GFR at 6 or 12 months after surgery.

conclusionsUrinary aminopeptidases are a potential tool for the early diagnosis of CSA-AKI, with GluAp being the most effective marker for diagnosing stage 2 or 3 of AKI at ICU admission. GluAp and DPP4 serve as predictive biomarkers for a decrease in GFR.

Indexed as

Acute Kidney InjuryBiomarkersCardiac Surgical ProceduresAcetylglucosaminidaseAgedAminopeptidasesCreatinineDipeptidyl Peptidase 4FemaleGlomerular Filtration RateHumansLipocalin-2MaleMiddle AgedAcetylglucosaminidaseAminopeptidasesBiomarkersCreatinineDipeptidyl Peptidase 4Lipocalin-2acute kidney injuryaminopeptidasesbiomarkersglomerular filtration raterenal replacement therapytubular lesions

Identifiers

PMID39334816
PMCPMC11430521

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