Evidence map›Paper›PMID 39334814›Full record

ArticleBiomolecules2024

Role of NHERF1 in MicroRNA Landscape Changes in Aging Mouse Kidneys.

Anish Jain, Hyun Jun Jung, Joseph Aubee, Jahn N O'Neil, Laila A Muhammad, Shaza Khan, Karl Thompson, Maurice B Fluitt, Dexter L Lee, Carolyn M Klinge and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anish JainDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.
Hyun Jun JungDivision of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-0519-5858
Joseph AubeeDepartment of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA.
Jahn N O'NeilDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.
Laila A MuhammadDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.
Shaza KhanDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.
Karl ThompsonDepartment of Microbiology, Howard University College of Medicine, Washington, DC 20059, USA.ORCID 0000-0001-6182-9507
Maurice B FluittDepartment of Medicine, Howard University College of Medicine, Washington, DC 20059, USA.
Dexter L LeeDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.
Carolyn M KlingeDepartment of Biochemistry and Molecular Genetics, University of Louisville School of Medicine, Louisville, KY 40202, USA.ORCID 0000-0002-3358-4378
Syed J KhundmiriDepartment of Physiology, Howard University College of Medicine, Washington, DC 20059, USA.

Funding

Advancing aging research through development of minority GerontologistsR25AG047843 · NIA · HOWARD UNIVERSITY · PI DUTTAROY, ATANU · 2014 to 2024
$3.3M
Dopamine-mediated regulation of blood pressure in aging: Role of NHERF-1R21AG047474 · NIA · UNIVERSITY OF LOUISVILLE · PI KHUNDMIRI, SYED J · 2014 to 2015
$407k
American Heart Association 16GRNT31030019NIH HHS 1R21AG047474-03A1NIH HHS 1R25AG047843-05S2
6 · The paper itself

Abstract

MicroRNAs (miRNAs) play important roles in the regulation of cellular function and fate via post-transcriptional regulation of gene expression. Although several miRNAs are associated with physiological processes and kidney diseases, not much is known about changes in miRNAs in aging kidneys. We previously demonstrated that sodium hydrogen exchanger 1 (NHERF1) expression regulates cellular responses to cisplatin, age-dependent salt-sensitive hypertension, and sodium-phosphate cotransporter trafficking. However, the mechanisms driving these regulatory effects of NHERF1 on cellular processes are unknown. Here, we hypothesize that dysregulation of miRNA-mediated gene regulatory networks that induce fibrosis and cytokines may depend on NHERF1 expression. To address this hypothesis, we compared miRNA expression in kidneys from both male and female old (12-18-month-old) and young (4-7-month-old) wild-type (WT) and NHERF1 knockout (NHERF1

Indexed as

AgingKidneyMicroRNAsPhosphoproteinsSodium-Hydrogen ExchangersAnimalsCytokinesFemaleGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutCytokinesMicroRNAsPhosphoproteinssodium-hydrogen exchanger regulatory factorSodium-Hydrogen ExchangersagingkidneysmiR-153miRNAnuclear factor of activated T-cells (NFATc2/3)sodium-hydrogen exchanger regulatory factor-1

Identifiers

PMID39334814
PMCPMC11430241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.