Evidence map›Paper›PMID 39334773›Full record

ReviewAntioxidants (Basel, Switzerland)2024

Effects and Mechanisms of Lutein on Aging and Age-Related Diseases.

Jialu Ye, Jin Cheng, Ruogu Xiong, Haoqi Chen, Siyu Huang, Huabin Li, Jinzhu Pang, Xuguang Zhang, Huilian Zhu

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Anti-Aging Potential of Avocado Oil via Its Antioxidant Effects.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jialu YeDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Jin ChengDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Ruogu XiongDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0002-2978-0026
Haoqi ChenDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Siyu HuangDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Huabin LiDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.ORCID 0000-0003-2332-8554
Jinzhu PangMengniu Institute of Nutrition Science, Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot City 011050, China.
Xuguang ZhangMengniu Institute of Nutrition Science, Global R&D Innovation Center, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot City 011050, China.
Huilian ZhuDepartment of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging and age-related diseases are serious public health issues that are receiving growing attention from researchers. Lutein has a critical function in the prevention and management of these issues. Possible mechanisms mainly include suppressing inflammation and oxidative stress, regulating cell activity, and modulating the levels of toxic substances. In this narrative review paper, we sum up the most current developments in the study of the effects of lutein on aging and five age-related diseases (age-related macular degeneration, cataracts, Alzheimer's disease, Parkinson's disease, and osteoporosis), and fundamental mechanisms are reviewed. The bioavailability of lutein and the strategies to improve its bioavailability are discussed. This piece of work can bring a clearer comprehension of the protective effects of lutein against aging and age-related diseases and can be also helpful for developing lutein as functional food and dietary supplements for these age-related diseases.

Indexed as

age-related diseasesage-related macular degenerationagingAlzheimer’s diseasecataractluteinosteoporosisParkinson’s disease

Identifiers

PMID39334773
PMCPMC11428584

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.