Evidence map›Paper›PMID 39334728›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Aerobic Exercise Protects against Cardiotoxin-Induced Skeletal Muscle Injury in a DDAH1-Dependent Manner.

Fei Feng, Kai Luo, Xinyi Yuan, Ting Lan, Siyu Wang, Xin Xu, Zhongbing Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fei FengSport and Health Science Department, Nanjing Sport Institute, Nanjing 210000, China.
Kai LuoCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-0931-9582
Xinyi YuanCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Ting LanCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Siyu WangCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.
Xin XuSchool of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China.
Zhongbing LuCollege of Life Science, University of Chinese Academy of Sciences, Beijing 100049, China.ORCID 0000-0002-2717-4698

Funding

Beijing Natural Science Foundation 5222029Ministry of Science and Technology of the People's Republic of China 2020YFF0304503National Natural Science Foundation of China 82070250
6 · The paper itself

Abstract

Dimethylarginine dimethylaminohydrolase 1 (DDAH1) is a critical enzyme that regulates nitric oxide (NO) signaling through the degradation of asymmetric dimethylarginine (ADMA). Previous studies have revealed a link between the beneficial effects of aerobic exercise and the upregulation of DDAH1 in bones and hearts. We previously reported that skeletal muscle DDAH1 plays a protective role in cardiotoxin (CTX)-induced skeletal muscle injury and regeneration. To determine the effects of aerobic exercise on CTX-induced skeletal muscle injury and the role of DDAH1 in this process, wild-type (WT) mice and skeletal muscle-specific

Indexed as

cardiotoxinDDAH1exerciseoxidative stressskeletal muscle regeneration

Identifiers

PMID39334728
PMCPMC11428882

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.