Evidence map›Paper›PMID 39334726›Full record

ArticleAntioxidants (Basel, Switzerland)2024

Cystathionine Gamma-Lyase Regulates TNF-α-Mediated Injury Response in Human Colonic Epithelial Cells and Colonoids.

Francisco Arroyo Almenas, Gábor Törő, Peter Szaniszlo, Manjit Maskey, Ketan K Thanki, Walter A Koltun, Gregory S Yochum, Irina V Pinchuk, Celia Chao, Mark R Hellmich and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francisco Arroyo AlmenasDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Gábor TörőDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Peter SzaniszloDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Manjit MaskeyDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.ORCID 0000-0003-2461-1538
Ketan K ThankiDivision of Colorectal Surgery, Valley Health System, Las Vegas, NV 89119, USA.
Walter A KoltunDepartment of Surgery, Division of Colon & Rectal Surgery, The Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Gregory S YochumDepartment of Surgery, Division of Colon & Rectal Surgery, The Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA 17033, USA.
Irina V PinchukDepartment of Medicine, The Pennsylvania State University College of Medicine, Hershey, PA 16802, USA.
Celia ChaoDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Mark R HellmichDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.
Katalin MódisDepartment of Surgery, The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.ORCID 0000-0002-0706-9196

Funding

SURGICAL TRAINING IN GASTROINTESTINAL ENDOCRINOLOGYT32DK007639 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI RADHAKRISHNAN, RAVI S. · 1992 to 2022
$3.6M
Role of Hydrogen Sulfide in Colorectal TumorsR01CA175803 · NCI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HELLMICH, MARK R, SZABO, CSABA · 2014 to 2018
$1.5M
American Cancer Society RSG-21-027-01-CSMNCI NIH HHS R01 CA175803NIDDK NIH HHS T32 DK007639United States Department of Defense W81XWH2010641
6 · The paper itself

Abstract

Cystathionine gamma-lyase (CSE) and TNF-α are now recognized as key regulators of intestinal homeostasis, inflammation, and wound healing. In colonic epithelial cells, both molecules have been shown to influence a variety of biological processes, but the specific interactions between intracellular signaling pathways regulated by CSE and TNF-α are poorly understood. In the present study, we investigated these interactions in normal colonocytes and an organoid model of the healthy human colon using CSE-specific pharmacological inhibitors and siRNA-mediated transient gene silencing in analytical and functional assays in vitro. We demonstrated that CSE and TNF-α mutually regulated each other's functions in colonic epithelial cells. TNF-α treatment stimulated CSE activity within minutes and upregulated CSE expression after 24 h, increasing endogenous CSE-derived H

Indexed as

colonic epithelial cellscolonoidscystathionine gamma-lyasehydrogen sulfideinflammationTNF-α

Identifiers

PMID39334726
PMCPMC11428476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.