ArticleChildren (Basel, Switzerland)2024
Effects of Immersive Virtual Reality with Treadmill in Subjects with Rett Syndrome: A Pilot Study.
Article in Children (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Leisure-Time Physical Activity Interventions for Health Promotion in Individuals With Rett Syndrome: Scoping Review.JMIR rehabilitation and assistive technologies · 2026Review
- Effectiveness of treadmill-based virtual-reality biofeedback training to improve gait function in children and adolescents with congenital and acquired brain injury.Scientific reports · 2025Observational
- Combined deep and reinforcement learning with gaming to promote healthcare in neurodevelopmental disorders: a new hypothesis.Frontiers in human neuroscience · 2025Article
- Impact of CAVE automatic virtual environment (CAVE) on user experience and health outcomes: A systematic review.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND/
objectivesRett syndrome is a rare neurodevelopmental disorder that can severely affect motor functioning, particularly walking. Previous training programs proposed treadmills as tools to increase walking endurance of patients with Rett syndrome, but these trainings did not include virtual reality (VR). The aim of this study was to assess the feasibility of a short treadmill training coupled to VR in girls with Rett syndrome.
methodsNine patients with Rett syndrome underwent a 3-day treadmill walking program performed in semi-immersive VR. During the training, the happiness index and performance metrics were collected. At the end of the training parents filled out the Suitability Evaluation Questionnaire (SEQ) and, when feasible, patients underwent a gait assessment.
resultsAll the subjects recruited performed the three GRAIL sessions and parents showed a good satisfaction and considered the integration of treadmill and VR a good possibility for future rehabilitative programs. Participants showed greater satisfaction in environments requiring walking and their attention increased during training sessions, hypothesizing the feasibility of longer trainings with treadmill and VR. Data collected from gait analysis provided insights, although preliminary, concerning differences in gait pattern amongst the recruited subjects.
conclusionsDespite the small sample size and limited training duration, the paper suggests that a walking training with a treadmill combined with VR can represent a new strategy for Rett rehabilitation.
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Registered trials
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