ArticleEuropean journal of clinical investigation2025
Dose-dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset.
Article in European journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Association of Weight Loss With Improvement in Metabolic Status Among People Eligible for the Specific Health Guidance Program.Circulation reports · 2026Article
- Relationship of Depression With Incident Cardiovascular Disease in Individuals With Chronic Kidney Disease.Circulation reports · 2026Article
- Population attributable fraction of modifiable risk factors for incident hypertension: an analysis of large-scale epidemiological cohort.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Age-Specific Association Between the Dietary Inflammatory Index and Depression Among Patients With Chronic Kidney Disease.Food science & nutrition · 2026Article
- Association of changes in body weight and waist circumference with a subsequent risk of developing hypertension in men requiring specific healthcare guidance.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association between chronic kidney disease and depression: evidence from the NHANES 2015-2018 and Mendelian randomization analysis.Clinical and experimental nephrology · 2025Article
- Integrated analysis identifies key genes underlying the bidirectional association between depression and renal failure.Scientific reports · 2025Article
- Dose-dependent association between estimated glomerular filtration rate and the subsequent risk of depression: An analysis of a nationwide epidemiological dataset.European journal of clinical investigation · 2025Article
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Authors and funding
14 authors.
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Abstract
backgroundAlthough the risk of depression is well-known in the patients with kidney dysfunction, especially at the late stages, little is known about the exact point at which the decline in estimated glomerular filtration rate (eGFR) begins to significantly increase the risk of depression. In the present study, we analysed a nationwide epidemiological dataset to investigate the dose-dependent association between baseline eGFR and a future risk of developing depression in a general population.
methodsWe retrospectively analysed 1,518,885 individuals (male: 46.3%) without a history of depression identified between April 2014 and November 2022 within a nationwide epidemiological database, provided by DeSC Healthcare (Tokyo, Japan). We investigated the association of eGFR with the incidence of depression using Cox regression analyses and also conducted cubic spline analysis to investigate the dose-dependent association between eGFR and depression.
resultsIn the mean follow-up of 1218 ± 693 days, 45,878 cases (3.0% for total participants, 2.6% for men and 3.3% for women) of depression were recorded. The risk of depression increased with the eGFR decline as well as the presence of proteinuria. Multivariable Cox regression analysis showed the hazard ratio (95% CI) of depression in each kidney function category (eGFR ≥90, 60-89, 45-59, 30-44, 15-29, and < 15 mL/min/1.73 m
conclusionsOur analysis using a large-scale epidemiological dataset presented the dose-dependent association between eGFR decline and the risk of depression, which highlights the importance of incorporating mental health assessments into the routine care of patients with kidney dysfunction, regardless of the stage of their disease.
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