Evidence map›Paper›PMID 39334235›Full record

ArticleOrphanet journal of rare diseases2024

COVID-19 risk factors and outcomes in individuals with stiff person syndrome spectrum disorders before and after omicron.

Hanyeh Afshar, Alexandra Simpson, Elena Taylor, Ashley Miles, Herbert R Chen, Scott D Newsome

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orphanet journal of rare diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanyeh AfsharJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Alexandra SimpsonJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Elena TaylorJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Ashley MilesJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Herbert R ChenJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Scott D NewsomeJohns Hopkins University School of Medicine, Baltimore, MD, USA. snewsom2@jhmi.edu.ORCID 0000-0002-5284-4681

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStiff person syndrome spectrum disorders (SPSD) are rare, disabling disorders of the nervous system that are associated with risk factors for Coronavirus disease 2019 (COVID-19). However, limited data exist on the overall impact of COVID-19 on SPSD.

methodsPatients with SPSD and COVID-19 who are followed at Johns Hopkins SPS Center were included. Demographics and SPSD characteristics along with COVID-19-specific data were recorded.

resultsThirty-five cases of SPSD with COVID-19 cases were reported during the study time period. Mean age of the cohort was 56 (SD ± 10) and most were female (66.7%). Eighty percent of the COVID-19 cases were confirmed with testing, and the rest were highly suggestive of COVID-19. COVID-19 comorbidities among patients were hypertension (n = 6), diabetes (n = 6), obesity (n = 5), and cardiovascular disease (n = 4). The majority of participants were on immune therapies and/or benzodiazepines. Out of the cases reported, only 2 required hospitalization, both of whom had diabetes, and one was on immunosuppressive therapy. The majority of cases were post-full-vaccination cases. Fever was the most common COVID-19-associated symptom. Transient neurological symptoms were also reported.

conclusionRisk factors for developing severe COVID-19 in SPSD appear to be the same as historical data in the general population. Importantly, COVID-19 did not appear to be associated with worsening SPSD post-COVID-19. Vaccination may have played a role in preventing severe cases of COVID-19.

Indexed as

COVID-19SARS-CoV-2Stiff-Person SyndromeAdultAgedComorbidityFemaleHumansMaleMiddle AgedRisk FactorsCOVID-19NeurologySPSDStiff person syndromeVaccination

Identifiers

PMID39334235
PMCPMC11428925

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.